Osteoarthritis:toward a comprehensive understanding of pathological mechanism

作     者：Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im 

作者机构：Department of BiochemistryRush University Medical Center Department of Orthopaedic SurgeryWashington University Department of Orthopaedics & TraumatologyLi Ka Shing Faculty of MedicineThe University of Hong Kong Department of PharmacyShanghai Ninth People’s HospitalShanghai Jiao Tong University School of Medicine School of Biomedical EngineeringScienceand Health SystemsDrexel University 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2017年第5卷第1期

页      面：1-13页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by NIH grants AR055915 and AR054465 to DC 

主　　题：OA Osteoarthritis:toward a comprehensive understanding of pathological mechanism ADAMTS NGF 

摘      要：Osteoarthritis （OA） is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently, there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway（s） controlling these pathological processes.