Increased Cortical Thickness in Male-to-Female Transsexualism
Increased Cortical Thickness in Male-to-Female Transsexualism作者机构：Center for Imaging Neurodegenerative Diseases US Department of Veterans Affairs Washington DC USA Center for Society & Genetics Department of Human Genetics UCLA School of Medicine Los Angeles USA Department of Psychiatry University of Jena Jena Germany Laboratory of Neuro Imaging Department of Neurology UCLA School of Medicine Los Angeles USA
出 版 物：《Journal of Behavioral and Brain Science》 (行为与脑科学期刊（英文）)
年 卷 期：2012年第2卷第3期
页 面：357-362页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Brain Cortex Gender Identity Disorder MRI Transgender Gender Dysphoria Gender Incongruence Gender Nonconformity
摘 要：Background: The degree to which one identifies as male or female has a profound impact on one’s life. Yet, there is a limited understanding of what contributes to this important characteristic termed gender identity. In order to reveal factors influencing gender identity, studies have focused on people who report strong feelings of being the opposite sex, such as male-to-female (MTF) transsexuals. Method: To investigate potential neuroanatomical variations associated with transsexualism, we compared the regional thickness of the cerebral cortex between 24 MTF transsexuals who had not yet been treated with cross-sex hormones and 24 age-matched control males. Results: Results revealed thicker cortices in MTF transsexuals, both within regions of the left hemisphere (i.e., frontal and orbito-frontal cortex, central sulcus, perisylvian regions, paracentral gyrus) and right hemisphere (i.e., pre-/post-central gyrus, parietal cortex, temporal cortex, precuneus, fusiform, lingual, and orbito-frontal gyrus). Conclusion: These findings provide further evidence that brain anatomy is associated with gender identity, where measures in MTF transsexuals appear to be shifted away from gender-congruent men.
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