Changes in the Physico-Chemical Properties of Human Kidney Cell Membranes during the Cancer Transformation
Changes in the Physico-Chemical Properties of Human Kidney Cell Membranes during the Cancer Transformation作者机构：Clinical Department of Urology Medical University of Bialystok Bialystok Poland Institute of Chemistry University in Bialystok Bialystok Poland Laboratory of Electrochemical Power Sources Faculty of Chemistry University of Warsaw Warsaw Poland
出 版 物：《Advances in Biological Chemistry》 (生物化学进展（英文）)
年 卷 期：2014年第4卷第4期
页 面：223-231页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Phospholipids Proteins Electric Charge Human Kidney
摘 要：Kidney tissue is particularly susceptible to reactive oxygen species attack which leads to development of cancer. During oxidative stress, membrane lipids and proteins are major targets of re-active oxygen species (ROS). This work is focused on changes of phospholipids, proteins content and electric charge that occur in cell membranes of kidney cancer of pT3 stage, grade G3 and with metastasis. Qualitative and quantitative phospholipid composition and the presence of integral membrane proteins were determined by high-performance liquid chromatography. Electrophoresis was used to determine the surface charge density of the human kidney cell membrane. It was shown that the process of cancer transformation was accompanied by an increase phospholipid levels and altered the level of integral proteins as determined by decrease phenylalanine, tyrosine, cysteine and arginine. Moreover, the process of cancer transformation significantly enhanced changes in the surface charge density of the human kidney cell membrane. Cell membrane structure and function are modified by neoplasm lesion.
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