Animal models of coronary heart disease

作     者：Jiawei Liao Wei Huang George Liu 

作者机构：Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Peking University Health Science Center Beijing 100191 China 

出 版 物：《The Journal of Biomedical Research》 (生物医学研究杂志（英文版）)

年 卷 期：2017年第31卷第1期

页      面：3-10页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：coronary heart disease animal models coronary atherosclerosis coronary arteriosclerosis 

摘      要：Cardiovascular disease,predominantly coronary heart disease and stroke,leads to high morbidity and mortality not only in developed worlds but also in underdeveloped *** dominant pathologic foundation for cardiovascular disease is atherosclerosis and,as to coronary heart disease,coronary atherosclerosis and resulting lumen stenosis,even total *** translational research,several animals,such as mice,rabbits and pigs,have been used as disease models of human atherosclerosis and related cardiovascular ***,coronary lesions are either naturally rare or hard to be fast induced in these models,hence,coronary heart disease induction mostly relies on surgical or pharmaceutical interventions with no or limited primary coronary lesions,thus unrepresentative of human coronary heart disease progression and *** this review,we describe the progress of animal models of coronary heart disease following either spontaneous or diet-accelerated coronary lesions.