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Isoflurane preconditioning induces ischemic tolerance in MCAO rats

Isoflurane preconditioning induces ischemic tolerance in MCAO rats

作     者:朱振华 熊利泽  

作者机构:DepartmentofAnesthesiologyXijingHospitalFourthMilitaryMedicalUniversityXi‘an710033Chian Departmen 

出 版 物:《第四军医大学学报》 (Journal of the Fourth Military Medical University)

年 卷 期:2001年第22卷第5期

页      面:474-476页

学科分类:1002[医学-临床医学] 100204[医学-神经病学] 100217[医学-麻醉学] 10[医学] 

基  金:The National Natural Science Foundation! (3 9670 -699) 

主  题:局灶性脑缺血 异氟醚 预处理 实验研究 

摘      要:INTRODUCTION The “ischemic tolerance in brain fou nded by Kitagawa et al[1] is an ideal model to investigate the mechanisms of cerebral ischemic damage and neuroprotection. But exposing patients to brief ischemic events before an antici pated cerebral ischemia occurs seems difficult and unacceptable in clinical practice. Therefore, some investigators studied the possibility of chemical preconditionin g which mimics ischemic preconditioning, and demonstrated that some chemicals coul d induce the ischemic tolerance in brain [2]. However, the clinical applic ation of these chemical substances is yet to be elucidated because of their toxicity or side ef fects. Recently, isoflurane and sevoflurane have been proved to be able to mimic ischemic preconditioning in myocardial ischemia[3-6]. Whether they could also induce the same effects in brain has not been reported yet. Therefore, the present stud y was undertaken to testify if isoflurane could induce ischemic tolerance in brain on middle cerebral artery occlusion (MCAO) rat model.

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