Impact of mycotoxin on immune response and consequences for pig health

作     者：Alix Pierron Imourana Alassane-Kpembi Isabelle P.Oswald 

作者机构：INRA UMR 1331 ToxAlim Research Centre in Food Toxicology Universite de Toulouse INP UMR 1331 ToxAlim BIOMIN Research Center 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2016年第2卷第2期

页      面：63-68页

学科分类：090603[农学-临床兽医学] 09[农学] 0906[农学-兽医学] 

基　　金：supported by a fellowship from CIFRE (2012/ 0572, jointly financed by the BIOMIN Holding GmbH, Association Nationale de la Recherche Technique and INRA) supported in part by the french project Tool4gutHealth, jointly financed by the Lallemand and the Region Midi-Pyrénées 

主　　题：Pig Mycotoxins Feed contamination Susceptibility to disease Immunity Vaccine efficacy 

摘      要：Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especially cereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the European Union, regulations and/or recommendations exist in pig feed for aflatoxins, ochratoxin A, fumonisins,zearalenone, and trichothecenes, deoxynivalenol and T-2 toxin. These mycotoxins have different toxic effects, but they all target the immune system. They have immunostimulatory or immunosuppressive effects depending on the toxin, the concentration and the parameter investigated. The immune system is primarily responsible for defense against invading organisms. The consequences of the ingestion of mycotoxin-contaminated feed are an increased susceptibility to infectious diseases, a reactivation of chronic infection and a decreased vaccine efficacy. In this review we summarized the data available on the effect of mycotoxins on the immune system and the consequences for pig health.