Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective
Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective作者机构：School of Biomedical SciencesFaculty of Medicinethe Chinese University of Hong Kong
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2016年第22卷第33期
页 面：7463-7477页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by General Research Fund,Research Grants Council of Hong Kong,No.CUHK462211,No.CUHK462713 and No.14102714 National Natural Science Foundation of China,No.81101888 and No.8142730 Direct Grant from CUHK
主 题：Bile acids Pancreatic adenocarcinoma Pancreatitis Metabolic syndrome
摘 要：The role of bile acids in colorectal cancer has been well documented,but their role in pancreatic cancer remains unclear. In this review,we examined the risk factors of pancreatic cancer. We found that bile acids are associated with most of these factors. Alcohol intake,smoking,and a high-fat diet all lead to high secretion of bile acids,and bile acid metabolic dysfunction is a causal factor of gallstones. An increase in secretion of bile acids,in addition to a long common channel,may result in bile acid reflux into the pancreatic duct and to the epithelial cells or acinar cells,from which pancreatic adenocarcinoma is derived. The final pathophysiological process is pancreatitis,which promotes dedifferentiation of acinar cells into progenitor duct-like cells. Interestingly,bile acids act as regulatory molecules in metabolism,affecting adipose tissue distribution,insulin sensitivity and triglyceride metabolism. As a result,bile acids are associated with three risk factors of pancreatic cancer: obesity,diabetes and hypertriglyceridemia. In the second part of this review,we summarize several studies showing that bile acids act as cancer promoters in gastrointestinal cancer. However,more question are raised than have been solved,and further oncological and physiological experiments are needed to confirm the role of bile acids in pancreatic cancer carcinogenesis.
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