Exploring the metabolic syndrome: Nonalcoholic fatty pancreas disease

作     者：Roberto Catanzaro Biagio Cuffari Angelo Italia Francesco Marotta 

作者机构：Department of Clinical and Experimental MedicineGastroenterology and Hepatology ServiceInternal Medicine UnitUniversity Hospital Policlinico 'G. Rodolico'University of Catania 95123 Catania Italy ReGenera Research Group for Aging-Intervention 20144 Milano Italy 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2016年第22卷第34期

页      面：7660-7675页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Metabolic syndrome Nonalcoholic fatty liver disease Pancreatic steatosis Pancreatic lipomatosis Nonalcoholic fatty pancreas disease Fatty pancreas Pancreatic fat Pancreatic fatty replacement Pancreatic fatty infiltration Pancreatic cancer 

摘      要：After the first description of fatty pancreas in 1933,the effects of pancreatic steatosis have been poorly investigated,compared with that of the liver. However,the interest of research is increasing. Fat accumulation,associated with obesity and the metabolic syndrome(Met S),has been defined as fatty infiltration or nonalcoholic fatty pancreas disease(NAFPD). The term fatty replacement describes a distinct phenomenon characterized by death of acinar cells and replacement by adipose tissue. Risk factors for developing NAFPD include obesity,increasing age,male sex,hypertension,dyslipidemia,alcohol and hyperferritinemia. Increasing evidence support the role of pancreatic fat in the development of type 2 diabetes mellitus,Met S,atherosclerosis,severe acute pancreatitis and even pancreatic cancer. Evidence exists that fatty pancreas could be used as the initial indicator of ectopic fat deposition,which is a key element of nonalcoholic fatty liver disease and/or Met S. Moreover,in patients with fatty pancreas,pancreaticoduodenectomy is associated with an increased risk of intraoperative blood loss and post-operative pancreatic fistula.