High on food： the interaction between the neural circuits for feeding and for reward
High on food： the interaction between the neural circuits for feeding and for reward作者机构：Child Health Institute of New Jersey Department of Neuroscience and Cell Biology Rutgers University Robert Wood Johnson Medical School New Brunswick NJ 08901 USA Department of Biological Chemistry Institute for Life Sciences The Hebrew University of Jerusalem 91904 Jerusalem Israel The Edmond and Lily Safra Center for Brain Sciences The Hebrew University of Jerusalem 91904 Jerusalem Israel
出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)
年 卷 期：2015年第10卷第2期
页 面：165-176页
核心收录：
学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 090502[农学-动物营养与饲料科学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 0905[农学-畜牧学] 09[农学] 0836[工学-生物工程] 071002[理学-动物学] 0713[理学-生态学]
基 金：the generous support from the US-Israel Binational Science Foundation (BSF)
主 题：feeding neural circuitry hedonic reward mesolimbic system dopamine hypothalamus
摘 要：Hunger, mostly initiated by a deficiency in energy, induces food seeking and intake. However, the drive toward food is not only regulated by physiological needs, but is motivated by the pleasure derived from ingestion of food, in particular palatable foods. Therefore, feeding is viewed as an adaptive motivated behavior that involves integrated communication between homeostatic feeding circuits and reward circuits. The initiation and termination of a feeding episode are instructed by a variety of neuronal signals, and maladaptive plasticity in almost any component of the network may lead to the development of pathological eating disorders. In this review we will summarize the latest understanding of how the feeding circuits and reward circuits in the brain interact. We will emphasize communication between the hypothalamus and the mesolimbic dopamine system and highlight complexities, discrepancies, open questions and future directions for the field.
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