Evaluation of hypoxia inducible factor targeting pharmacological drugs as antileishmanial agents

作     者：Marina Dal’Bo Pelegrini Juliana Biar Pereira Solange dos Santos Costa Myriam Janeth Salazar Terreros Adriana Degrossoli Selma Giorgio 

作者机构：Department of Animal BiologyBiology InstituteUniversidade Estadual de CampinasCampinasSao PauloBrazil 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2016年第9卷第7期

页      面：633-638页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo,Conselho Nacional de Desenvolvimento Científico e Tecnologico (NO.2009/10771-9) Coordenacao de Aperfeicoamento de Pessoal de Nível Superior (NO.301052/2009-3),Brazil 

主　　题：Leishmaniosis Hypoxia inducible factor Resveratrol Echinomycin CdCl2 Mimosine 

摘      要：Objective:To evaluate whether hypoxia inducible factor(HIF-1α) targeting pharmacological drugs,echinomycin,resveratrol and CdCl_2 which inhibit HIF-1α stimulation,and mimosine,which enhances the stability of HIF-1α present antileishmanial ***:The leishmanicidal effect of drugs was evaluated in mouse macrophages and Balb/c mouse model for cutaneous ***:Resveratrol and CdCl_2 reduced the parasite load [IC50,(27.3±2.25) μM and(24.8±0.95) μM,respectively].The IC50 value of echinomycin was(22.7±7.36) nM and mimosine did not alter the parasite load in primary *** macrophage viability IC50 values for resveratrol,echinomycin and CdCl_2 and mimosine were 40 μM,100 nM, 200 μM and2 000 μM,*** vivo no differences between cutaneous lesions from control,resveratrol-and echinomycin-treated Balb/c mice were ***:Resveratrol,echinomycin and CdCl_2 reduce parasite survival in *** HIF-1α targeting pharmacological drugs require further study to more fully determine their anti-Leishmania potential and their role in therapeutic strategies.