Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6

作     者：Cassie A Schumacher Danese M Joiner Kennen D Less Melissa Oosterhouse Drewry Bart O Williams 

作者机构：Center for Cancer and Cell BiologyProgram in Skeletal Disease and Tumor MicroenvironmentVan Andel Research Institute 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2015年第3卷第4期

页      面：235-245页

核心收录：

学科分类：10[医学] 

基　　金：supported by the Van Andel Research Institute NIH/NIAMS R01 grant AR053293 to BOW 

主　　题：carrying Collagen displayed deletion engineered transgene viable embryogenesis redundant embryonic 

摘      要：Mice carrying Collagen2a1-cre-mediated deletions of Lrp5 and/or Lrp6 were created and *** lacking either gene alone were viable and fertile with normal knee *** in which both Lrp5 and Lrp6 were conditionally ablated via Collagen2al-cre-mediated deletion displayed severe defects in skeletal development during *** addition,adult mice carrying Collagen2al-cre-mediated deletions of Lrp5 and/or Lrp6 displayed low bone mass suggesting that the Collagen2a1-cre transgene was active in cells that subsequently differentiated into *** both embryonic skeletal development and establishment of adult bone mass,Lrp5 and Lrp6 carry out redundant functions.