Progress and perspectives on targeting nanoparticles for brain drug delivery

作     者：Huile Gao 

作者机构：Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2016年第6卷第4期

页      面：268-286页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(Nos.31571016 and 81402866) 

主　　题：Brain targeting Nanoparticles Dual targeting Intranasal delivery Blood–brain barrier 

摘      要：Due to the ability of the blood–brain barrier(BBB) to prevent the entry of drugs into the brain, it is a challenge to treat central nervous system disorders pharmacologically. The development of nanotechnology provides potential to overcome this problem. In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier(BBTB), and nose-to-brain barrier. Delivery strategies are focused on overcoming the BBB, directly targeting diseased cells in the brain, and dual-targeted delivery. The major concerns and perspectives on constructing brain-targeted delivery systems are discussed.