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Neural Regeneration Research 2022年第9期17卷 1881-1884页

作者： Christian Humpel Laboratory of Psychiatry and Experimental Alzheimer’s Research Medical University of InnsbruckInnsbruckAustria

Neurodegenerative brain disorders are a major burden in our society,such as Alzheimer´s disease.In order to repair or prevent such diseases,drugs are designed which enter the brain,but the blood-brain barrier limits their entry and the search for alternative pathways is important.Recently,we reported that Intranasal delivery of the amyloid-beta degrading enzyme neprilysin eliminated amyloid-beta plaques in transgenic Alzheimer´s disease mice.This review describes the anatomical structure of the Intranasal pathway,explains the Intranasal delivery of pure neprilysin,cell-loaded neprilysin(platelets)and collagen-embedded neprilysin to destruct amyloid-beta plaques in Alzheimer´s disease in transgenic APP_SweDI mice and hypothesizes why this may cause compensation and why the amyloid-beta cascade hypothesis may fail.

关键词： amyloid-beta amyloid-beta degrading enzyme clear plaque collagen biomaterial Intranasal neprilysin nose-to-brain

New idea to promote the clinical applications of stem cells or their extracellular vesicles in central nervous system disorders:Combining with Intranasal delivery

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3215-3232页

作者： Yaosheng Li Honghui Wu Xinchi Jiang Yunfei Dong Juanjuan Zheng Jianqing Gao Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Dr.Li Dak Sum&Yip Yio Chin Center for Stem Cell and Regenerative Medicine Zhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China

The clinical translation of stem cells and their extracellular vesicles(EVs)-based therapy for central nervous system(CNS) diseases is booming. Nevertheless, the insufficient CNS delivery and retention together with the invasiveness of current administration routes prevent stem cells or EVs from fully exerting their clinical therapeutic potential. Intranasal(IN) delivery is a possible strategy to solve problems as IN route could circumvent the brain-blood barrier non-invasively and fit repeated dosage regimens. Herein, we gave an overview of studies and clinical trials involved with IN route and discussed the possibility of employing IN delivery to solve problems in stem cells or EVs-based therapy. We reviewed relevant researches that combining stem cells or EVs-based therapy with IN administration and analyzed benefits brought by IN route. Finally, we proposed possible suggestions to facilitate the development of IN delivery of stem cells or EVs.

关键词： Stem cells Extracellular vesicles Central nervous system disorders Intranasal Clinical translation Stroke Neurodegenerative disease Glioma

Intranasal glial heterotopia in an infant boy

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Pediatric Investigation 2021年第1期5卷 69-72页

作者： Wei Zhang Lixing Tang Wentong Ge Department of Otorhinolaryngology Head and Neck SurgeryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Introduction:Nasal glial heterotopia is a rare congenital developmental disorder characterized by meningeal epithelium and/or glial components.Case presentation:A 2-month-old boy presented for treatment of a congenital mass in the right nasal cavity near the pharynx.The preoperative diagnosis was congenital Intranasal neoplasm.Nasal endoscopic resection of the nasopharyngeal mass was performed under general anesthesia.Histological findings in the resected tissue supported a diagnosis of Intranasal glial heterotopia.The surgical outcome was good and no surgical site infection occurred.During 1 year of follow-up,the patient did not exhibit recurrence of heterotopia or related symptoms.Conclusion:Transnasal endoscopic surgery is recommended for patients with Intranasal glial heterotopia.Thorough preoperative imaging should be performed before glioma resection.The mass should be differentiated from encephalocele to prevent cerebrospinal fluid leakage and meningitis.

关键词： Intranasal Glial heterotopia Infant Encephalocele

Intranasal ketamine for the treatment of patients with acute pain in the emergency department

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World Journal of Emergency Medicine 2016年第1期7卷 19-24页

作者： Roshana Shrestha Samita Pant Ashis Shrestha Kabita Hada Batajoo Rashmi Thapa Sumana Vaidya Department of General Practice and Emergency Medicine Manmohan Medical College and Teaching Hospital Department of General Practice and Emergency Medicine Patan Academy of Health Sciences Department of General Practice and Emergency Medicine KIST Medical College Hospital Department of General Practice and Emergency Medicine KMC Medical College Hospital

BACKGROUND:Pain in the emergency department(ED)is common but undertreated.The objective of this study was to examine the efficacy and safety of Intranasal(IN)ketamine used as an analgesic for patients with acute injury with moderate to severe pain.METHODS:This study was a cross sectional,observational study of patients more than 8 years old experiencing moderate to severe pain[visual analog score(VAS)>50 mm].The initial dose of IN ketamine was 0.7 mg/kg with an additional dose of 0.3 mg/kg if VAS was more than 50 mm after 15minutes.Pain scores and vital signs were recorded at 0,15,30 and 60 minutes.Side-effects,sedation level and patient's satisfaction were also recorded.The primary outcome was the number of patients achieving≥20 mm reductions in VAS at 15 minutes.Other secondary outcome measures were median reduction in VAS at 15,30 and 60 minutes,changes of vital signs,adverse events,satisfaction of patients,and need for additional ketamine.RESULTS:Thirty-four patients with a median age of 29.5 years(IQR 17.5–38)were enrolled,and they had an initial median VAS of 80 mm(IQR 67–90).The VAS decreased more than 20 mm at15 minutes in 27(80%)patients.The reduction of VAS from baseline to 40 mm(IQR 20–40),20 mm(IQR 14–20)and 20 mm(IQR 10–20)respectively at 15,30 and 60 minutes(P<0.001).No critical changes of vital signs were noted and adverse effects were mild and transient.CONCLUSION:This study showed that IN ketamine is an analgesic choice for patients with acute injury in moderate to severe pain in an overcrowded and resource limited ED.

关键词： Analgesia Intranasal Ketamine Pain Visual analog score

Intranasal sufentanil combined with Intranasal dexmedetomidine: A promising method for non-anesthesiologist sedation during endoscopic ultrasonography

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World Journal of Clinical Cases 2022年第23期10卷 8428-8431页

作者： Yong Wang Zhi-Jun Ge Chao Han Department of Anesthesiology The Affiliated Yixing Hospital of Jiangsu UniversityYixing 214200Jiangsu ProvinceChina School of Medical Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina

Intranasal sufentanil combined with Intranasal dexmedetomidine exhibited an estimated sedation success probability as high as 94.9%,higher satisfaction scores,and only minor adverse events during endoscopic ultrasonog... 详细信息

关键词： Intranasal Sufentanil Dexmedetomidine Sedation Endoscopic Ultrasonography

Intranasal ketamine as an analgesic agent for acute pain management in emergency department: A literature review

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Journal of Acute Disease 2018年第6期7卷 241-246页

作者： Abdolghader Pakniyat Morteza Qaribi Dorin Rahnama Hezaveh Ali Abdolrazaghnejad Department of emergency Medicine Faculty of MedicineKurdistan University of medical sceincesSanandajIran Department of Emergency Medicine School of MedicineArak University of Medical SciencesArakIran School of Medicine Medical University of LublinLublinPoland Department of Emergency Medicine Khatam-Al-Anbia HospitalZahedan University of Medical SciencesZahedanIran

Ketamine is a well-known dissociative anesthetic agent, and has been used over 50 years. Intranasal pathway is a mucosal way for absorbing agents to directly affect in brain via olfactory sheets, bypassing first pass metabolism and the blood brain barrier. The current uses of Intranasal ketamine as an analgesic agent for acute pain management in emergency department are discussed in this review article. Using 'ketamine', 'pain or analgesia', and'Intranasal' as keywords, a search of google scholar, Pubmed, web of science, and Medline database from 1970 until 2017 was performed. Finally, from 1204 papers extracted via primary search, 1088 papers were omitted and finally 10 studies were considered for further assessment. There were four observational studies, one case series and report and 5 clinical trials. Ketamine was used for acute pain control due to musculoskeletal trauma, burns, and painful procedures. A total of 390 cases were included in these studies. The studies used ketamine with doses ranging 0.45-1.25 mg/kg via Intranasal pathway. Intranasal ketamine provides relatively rapid, well tolerated, and clinically significant analgesia for emergency department patients. Considering the lack of adequate studies and undetermined Intranasal dose, it is better to conduct further high quality investigation in both adults and pediatrics.

关键词： Administration Intranasal Emergency department Ketamine Pain management Review literature

Comparison of pharmacokinetics of Alprazolam after Intranasal and intragastric administration in rats

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沈阳药科大学学报 2008年第S1期25卷 101-102页

作者： GAO Yun-sheng,FEI Hong-rong,LI Ke,XIN Xiao-ming,QU Xiao-lan,QI Yong-xiu(School of Pharmacy,Taishan Medical University,Taian 271016,China)

Objective To compare the pharmacokinetics of Alprazolam after Intranasal and intragastic administration in rats and evaluate the practicability of Alprazolam as a nasal drug delivery system.Methods 12 rats were randomly divided into two groups.The fate of drug in the serum of rats was monitered after Intranasal and intragastic administration of Alprazolam 2 mg·kg-1.Serum levels of Alprazolam were determined by reversed-phase HPLC with Diode array detectors(DAD).Chromatographic conditions were adopted with ODS column as solid phase,methanaol-0.02 M ammonium acetate(pH=5.0)(60∶40)as mobile phase at a flow rate of 1.0 mL·min-1.The detection wavelength was 223 nm.The concentration-time data were analyzed using 3P87 program,and the pharmacokinetic parameters were compared by t-test.Results The pharmacokinetic characteristics were fit to two and one compartment opened model after Intranasal and intragastic administration of Alprazolam,respectively.The drug absorption was quicker and the serum concentrations of Alprazolam was significantly higher in rats after Intranasal administration group than that intragastic administration group(P0.05).Means of pharmacokinetic parameters in Intranasal and intragastic groups were:Ka 37.35±22.98 vs 11.57±12.47 h-1(P0.05),t1/2β(t1/2Ke)2.51±0.99 vs 2.54±0.97 h(P>0.05),tmax 0.156±0.069 vs 0.618±0.414 h(PIntranasal administration.And the serum concentration and bioavailability can be significantly increased after Intranasal administration,which may be an effective preparation as nasal drug delivery system.

关键词： Alprazolam Intranasal administration pharmacokinetics RP-HPLC

The optimum dose of Intranasal remifentanil for laryngeal mask airway insertion during sevoflurane induction in children:a randomized controlled trial

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The optimum dose of intranasal remifentanil for laryngeal ma...

Bilateral congenital dacryocystoceles with Intranasal mucoceles in the neonate: Case report and review of literature

2016中国中西医结合麻醉学会[CSIA]年会暨第三届全国中西医结合麻醉学术研讨会、河南省中西医结合学会麻醉专业委员会成立大会

作者： Yusheng Yao Yang Yang Yanqing Chen Department of Anesthesiology The Shengli ClinicalMedicalCollegeFujian Medical University

Objective:The purpose of this study was to determine the optimum dose of Intranasal remifentanil required to produce satisfactory laryngeal mask airway(LMA) insertion conditions during inhalation indu

关键词： volatile anesthetics sevoflurane potency premedication Intranasal opioid remifentanil laryngeal mask airway

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Open Journal of Pediatrics 2012年第2期2卷 178-180页

作者： Kenneth M. Wong Adrian W. Jachens John Bortz Augustine Moscatello Department of Ophthalmology Westchester Medical Center New York USA Department of Otolaryngology-Head and Neck Surgery New York Eye and Ear Infirmary New York USA Department of Otolaryngology-Head and Neck Surgery Westchester Medical Center New York USA

Congenital dacryocystoceles with Intranasal mucoceles are an uncommon entity. The overwhelming majority of reported cases are unilateral in nature. We present a rare case of a neonate with bilateral congenital dacryocystoceles with Intranasal mucoceles. Management of dacryocystoceles includes medical and surgical treatment. Literature review revealed 186 reported cases of congenital dacryocystoceles with 82 associated with Intranasal mucoceles. Prevalence rates ranged between 11% to 100%. Our case highlights the importance of nasal endoscopy in the work up and identification given the high prevalence rate of Intranasal mucocele component in patients with congenital dacryocystoceles.

关键词： Dacryocystocele Intranasal Mucocele Amniotocele Lacrimal Sac Cyst

Case of Advanced Recurrent Glioblastoma Successfully Treated with Monoterpene Perillyl Alcohol by Intranasal Administration

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Journal of Cancer Therapy 2011年第1期2卷 16-21页

作者： C. O. Da Fonseca Raphael M. Teixeira Ricardo Ramina Giovana Kovaleski Júlio Thome Silva Janaína Nagel Thereza Quirico-Santos Department of General and Specialized Surgery Unit of Clinical Research Fluminense Federal University Institute of Biology Fluminense Federal University Institute of Neurology of Curitiba

We report a case of recurrent glioblastoma (GBM) successfully treated with the Ras inhibitor monoterpene perillyl alcohol by Intranasal administration. A 37-years-old white woman had been previously submitted to three neurosurgical procedures, in June 2000 for radical tumor excision of grade II astrocytoma;in July 2003 for first recurrence of type IV glioma and in August 2004 for GBM recurrence. After last surgery, patient started a new cycle of chemotherapy but was refractory to treatment, presented clinical adverse effects and resonance image scan showed no reduction of tumoral lesion. Patient was then considered out of therapeutic possibilities and indicated for supportive treatment. On March 2005 patient joined Phase I/II clinical trial for assess the efficacy of the monoterpene POH, a Ras inhibitor. POH was administered by Intranasal route four times a day (268 mg daily) as single chemotherapy agent. Image scans performed 3 and 5 years later revealed marked reduction of enhancing lesion. This illustrative case demonstrates that Intranasal administration of the monoterpene POH as a single agent was an effective therapeutic strategy capable to sustain long-term regression of recurrent glioma without clinical and laboratory toxicity.

关键词： Glioblastoma Long-term Survival Perillyl Alcohol Intranasal Administration