Evaluation of anti-aphthous activity of decoction of Nicotiana tabacum leaves as a mouthwash： a placebo-controlled clinical study

作     者：Siavash Vaziri Mahdi Mojarrab Mohammad Hosein Farzaei Farid Najafi Ali Ghobadi 

作者机构：Department of Infectious Disease Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah *** Iran Pharmaceutical Sciences Research CenterKermanshah University of Medical Sciences Kermanshah *** Iran Pharmaceutical Sciences Research Center Kermanshah University of Medical SciencesKermanshah *** Iran Kermanshah University of Medical SciencesKermanshah *** Iran Department of Traditional Pharmacy School of Traditional Medicine Tehran University of Medical Sciences Tehran *** Iran 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2016年第36卷第2期

页      面：160-164页

核心收录：

学科分类：1005[医学-中医学] 100511[医学-中医五官科学] 10[医学] 

主　　题：Stomatitis aphthous Tobacco Pain Ul cer Medicine Traditional Complementary thera pies Mouthwashes 

摘      要：OBJECTIVE: To determine the effects of decoction derived from the leaves of Nicotiana tabacum(L.)as a mouthwash on minor recurrent ***: A randomized double-blinded placebo-controlled clinical trial was conducted on 60 patients with minor recurrent aphthous. Treatment comprised of application of tobacco or placebo mouthwash(10 m L 3 times a day) for 5 days. Clinical evaluation included pain level using a visual analog scale and ulcer size on days 1, 3, and 5 were measured. Adverse effects after mouthwash application were recorded, and the oral mucosa was examined by the investigator at each ***: A total of 54 subjects with the mean age(38 ± 10) years fulfilled the study. No minor and major adverse effects were observed. In the treatment group, ulcer pain score was decreased by 79.2%and 93.8% and ulcer size was reduced by 69.1%and 92.2%(days 3 and 5, respectively), which was significantly greater than the control group(P 0.01).CONCLUSION: The decoction prepared with of Nicotiana tabacum leaves, used as mouthwash are well-tolerated and safe, and can be used for the management of recurrent aphthous.