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The Local Immunity of the Oral Cavity in Women with Recurrent Aphthous stomatitis Associated with Urogenital Infection

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Open Journal of Stomatology 2019年第1期9卷 1-8页

作者： Оlga А. Uspenskaya Larisa N. Kazarina Еlena А. Shevchenko Josef Herbert Department of Therapeutic Stomatology Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Department of Propaedeutic Dentistry Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Department of Pathological Physiology Federal State Budgetary Educational Institution of Higher Education &laquo Privolzhsky Research Medical University» of the Ministry of Health of the Russian Federation Nizhny Novgorod Russia Dentist Running in Own Practice Sch&ouml nebeck Germany

This paper studied the dynamics of local immunity factors of the oral cavity in women with recurrent aphthous stomatitis against the background of urogenital infection. The research proves the maximum efficacy of hydroxyzine hydrochloride, aminodihydrophthalasindione sodium and Eplan used in multiple treatments of recurrent aphthous stomatitis in patients with urogenital infection as evidenced by a marked reduction in the coefficient of local immunity factors balance, which is observed as early as on day 7 of the therapy provided. Moreover, the findings show the growth of immunological parameters of oral fluid (lysozyme and SIgA), the normalization of the coefficient of local immunity factors balance in the treatment of recurrent aphthous stomatitis in women with urogenital infection, the improvement being observed 3 months after the treatment suggesting a favorable local immunity of the oral cavity.

关键词： Hydroxyzine Hydrochloride Aminodihydrophthalasindione Sodium Eplan Chronic Recurrent Aphthous stomatitis Coefficient of Local Immunity Factors Balance Secretory IgA Lysozyme Immunoglobulin A G

Evaluation of a Newly Developed Laser Pen as a Home Care Device for Pain Reduction of Recurrent Aphthous stomatitis (Preliminary Study)

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International Journal of Clinical Medicine 2015年第1期6卷 19-25页

作者： Maziar Mir Seyed Masoud Mojahedi Hassan Adalatkhah Jan Tunér Amir Mansour Shirani Roshan Babaalipour Masoud Shabani Conservative Dentistry RWTH International Academy Aachen Germany Deputy for Research Ardebil University of Medical Sciences Ardebil Iran Private Dental Clinic Gr&aumlngesberg Sweden Oral Medicine Department Dental School of Islamic Azad University Khorasgan Iran Science Department Islamic Azad University Ardebil Iran

Objective: The aim of this survey is to evaluate the effect of a new developed laser pen as a home care device for patients’ pain reduction with recurrent aphthous stomatitis. Background data: Recurrent aphthous stomatitis (RAS) is one of the most common and painful ulcers in the oral cavity. Low Level Laser Therapy (LLLT) has been used successfully for reducing pain and healing time in comparison with corticosteroids and placebo in some studies. But these treatments are done in the clinics and it seems that there is no report of the laser treatment as a home care device up to this study. Methods: This was a prospective, randomized trial pilot study. Thirty patients with RAS were divided into three similar groups. The group one (n = 10) was treated with a diode laser, 660 nm, 40 mw, continuous wave, 1.2 J, 6 J/cm2, for five consecutive days (twice per day, 30 seconds each session). The second group (n = 10) was treated with a topical triamcinolone (adcortyl in orabase) ointment four times per day and the third group (n = 10) was treated with placebo (red light pen) the same way as Group 1. All the patients were evaluated with a Visual Analogue Scale (VAS) before and after treatment on the consecutive days. The data was analysed by one way ANOVA and PostHoc tests. Results: The results show that the laser pen and triamcinolon in orabase ointment have similar results and both have better results than placebo in the control of the recurrent aphthous stomatitis pain (p value: 0.001). Conclusion: In this clinical pilot study the laser pen as a home care device seems to be useful for the treatment of RAS.

关键词： Low Level Laser Therapy Recurrent Aphthous stomatitis Pain Corticosteroid

Treatment of Recurrent Aphthous stomatitis by 100% Topical Pumpkin Seed Oil

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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第4期7卷 324-335页

作者： Khalifa E. Sharquie Adil A. Noaimi Tuqa M. Latif Department of Dermatology College of Medicine University of Baghdad Iraqi and Arab Board for Dermatology and Venereology Baghdad Teaching Hospital Medical City Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Medical City Baghdad Iraq

Background: Recurrent aphthous stomatitis (RAS) is a major oral health problem, where its etiopathogenesis is not well understood. Accordingly, its therapy whether topical or systemic can induce clearance, but the relapse rate is high. Objective: To use 100% topical pumpkin seed oil in RAS as it has many actions as anti-inflammatory and antioxidant effects. Patients and Methods: This single, blind, clinical, therapeutic trial was conducted in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq, during February 2015-August 2016. Twenty-five patients with RAS were included in this work. After full history and clinical examination, the clinical diagnosis was established. Oral clinical manifestation index score (OCMI) was carried out before, during and after stopping therapy to assess the different parameters of this score. 100% Topical pumpkin seed oil was given two times daily for 3 months during which short term assessment for each patient was done by using OCMI before, after 4 days and after 8 days of therapy in addition to assessing the mean size of largest diameter of ulcers in each visit to evaluate the therapeutic efficacy of the therapy, while long term assessment of the OCMI was done every month for 3 months after starting of the therapy to evaluate the prophylactic effect of the therapy. After 3 months, pumpkin seed oil was stopped and assessment of OCMI was done monthly for another 3 months to evaluate the remission action of pumpkin seed oil. Results: Twenty-five patients were included in this study: 15 (60%) males and 10 (40%) females. While their ages ranged from 9 - 60 (27.48 ± 11.97) years. The mean of OCMI before pumpkin seed oil therapy was ranged from 9 - 15 (12.96 ± 1.42), while after the therapy the mean started to decline to lower level within 4 days of therapy and was statistically significant (p < 0.0001) and continued to decline significantly till the end of third month of therapy (p < 0.0001). The percent reduction was 79.30% after 4 days of therapy and 94.38% after 8 day

关键词： Recurrent Aphthous stomatitis Pumpkin Seed Oil Therapy

Salivary cytokines and levels in denture stomatitis: An exploratory case-control study

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Open Journal of Stomatology 2012年第4期2卷 326-333页

作者： Silvana P. Barros Sandra Al-Tarawneh Sompop Bencharit Zvi Loewy Linda Gendreau Steven Offenbacher Department of Periodontology School of Dentistry University of North Carolina Chapel Hill USA Department of Pharmaceutical and Biomedical Sciences Touro College of Pharmacy New York USA Department of Pharmacology School of Medicine University of North Carolina Chapel Hill USA Department of Prosthodontics School of Dentistry University of North Carolina Chapel Hill USA GlaxoSmithKline Consumer Healthcare Parsippany USA

We aimed to evaluate the microbial and inflammatory characteristics associated with Denture stomatitis (DS) analyzing: l) Levels of salivary cytokines and cultivable C. albicans;2) DNA-DNA checkerboard on biofilm associated with mucosal tissue-bearing denture surfaces, 3) Serum C-reactive protein (CRP) levels. Thirty-two subjects were enrolled in the study with control (n = 17) and DS types II and III (n = 15) subjects. Samples were collected from unstimulated whole saliva, serum and swabs from denture surfaces. Salivary levels of inflammatory mediators and CRP were measured by multiplex. Samples from denture and mucosal surfaces were analyzed by DNA-DNA checkerboard. Saliva from DS subjects showed increase in IL-8 (p = 0.04) and IL-1β (p = 0.04) with trend for increase in IL-1β, TNFα and IL-6 levels. C. albicans higher counts in DS saliva (p = 0.03) showed association with elevated levels of IL-8 (p = 0.03) and IL-1α (p = 0.01). CRP levels were not different among groups (p = 0.74). DNA-DNA checkerboard analyses indicated typical periodontal pathogens below the detection threshold of 104 organisms on both denture and inflamed mucosal surfaces. The data suggest that DS is associated with elevation of salivary IL1 and IL-8 together with increased C. albicans. There was no evidence of systemic inflammation as measured by serum C-reactive protein levels.

关键词： Cytokines Serum C-Reactive Protein Denture C. albicans stomatitis Salivary

Therapeutic Role of Isotretinoin in the Management of Recurrent Aphthous stomatitis (Single-Blind Controlled Therapeutic Study)

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Journal of Cosmetics, Dermatological Sciences and Applications 2015年第1期5卷 15-21页

作者： Khalifa E. Sharquie Raad M. Helmi Adil A. Noaimi Mohand A. A. Kadhom Raafa K. Al-Hayani Scientific Council of Dermatology and Venereology-Iraqi and Arab Board for Medical Specializations Department of Dermatology and Venereology College of Medicine University of Baghdad Baghdad Iraq Department of Oral Medicine College of Dentistry Al-Mustansiriya University Baghdad Iraq School of Dentistry Faculty of Medical Science University of Duhok Duhok Iraq Department of Dermatology and Venereology Baghdad Teaching Hospital Baghdad Iraq

Background: Recurrent aphthous ulcer (RAS) is a common oral disease where its etiopathogenesis is not well elucidated. There was no effective curative therapy for this disease. Isotretinoin has been recently used in the treatment of Behcet’s disease. Objectives: To evaluate the efficacy and safety of isotretinoin in treating RAS and the long term remission of RAS. Patients and Methods: This single-blind controlled therapeutic study conducted in Department of Dermatology-Baghdad Teaching Hospital during February 2011-January 2012. Thirty patients with typical RAS were included in this work. Detailed history and full examination were done for all patients. They were given isotretinoin 20 mg orally once daily for three months to be seen on Day 14 firstly and then monthly to be assessed using the oral clinical manifestation index (OCMI). After isotretinoin was stopped three months later, patients were given placebo therapy for another 3 months. Results: The results of 30 treated patients were as follows: 17 (56.67%) males and 13 (43.33%) females with male to female ratio was 1.3:1. Their ages ranged from 12 - 60 (35.33 ± 12.06) years. The OCMI before isotretinoin therapy ranged from 7 - 17 (13.13 ± 2.55), while after therapy the mean started to decline to a lower level within the first 14 days (P = 0.103), and continued to decline significantly until the end of the first month of therapy (P = 0.023). Then the OCMI declined very significantly until the end of fourth month of therapy (P < 0.001). After that the mean started to increase until the end of the 5 months (with placebo) but it remained statistically significant compared with the baseline of mean of OCMI before treatment (P = 0.046). Then it continued to increase to become not significant at the end of 6 months of therapy (P = 0.107). Conclusion: Isotretinoin is an effective therapeutic and prophylactic promising remedy in treatment of RAS.

关键词： Recurrent Aphthous stomatitis Isotretinoin Iraq

Effects of Zingiber officinalis (WILLD.)ROSC.Membranes on minor recurrent aphthous stomatitis: a randomized pragmatic trial

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Journal of Traditional Chinese Medical Sciences 2018年第1期5卷 58-63页

作者： Qian Du Shenglou Ni Lin Guo Wenjie Song Kun Zhao Ni Liu Xinrong Wang Xun Ma Yanling Fu Quanming Tan Beijing University of Chinese Medicine Beijing 100029China Singapore Thong Chai Medical Institution Thong Chai Building 169874Singapore

Objective:To evaluate the effects of dried ginger rhizome (DGR;Zingiber officinalis (WILLD.) ROSC.),prepared as a membrane,in minor recurrent aphthous stomatitis (miRAS)treatment and explore its mechanism of action by detecting changes in levels of epidermal growth factor (EGF) and tumor necrosis factor (TNF)-α in saliva.Methods:Fifty-nine miRAS patients were enrolled in this study.The number of participants in the dried ginger rhizome membrane (DGRM) group was 30,and 29 were in the placebo membrane (PM) group.Sixty sealed envelopes containing either type of membrane were coded randomly.Investigators and participants were blinded to group assignments.A visual analog scale (VAS) was used for pain,follow-up information for healing time,and enzyme-linked immunosorbent assays to measure the concentrations of EGF and TNF-α.Results:In terms of VAS,there was a significant difference between pre-and post-DGRM treatment (P .05).A significant difference was observed in the healing time between the two groups (6.08 (2.712) vs.8.04 (2.142) days).The mean healing time in the DGRM group was shorter than that in the PM group (P <.05).In both groups,the salivary EGF concentration decreased significantly after treatment (P <.05),but the mean level in the DGRM group was significantly lower than that in the PM group (P <.05).The mean TNF-α level in both groups was increased significantly after treatment (P <.05),but patients who used DGRMs had a significantly lower level than that in the PM group (P <.05).Conclusion:The present study provides evidence that DGRMs are effective treatment for RAS.Dried ginger rhizome has obvious effects on pain relief,shortening of healing time,reducing the EGF level in saliva,and has an inhibitory effect on TNF-α release.

关键词： Dried ginger rhizome membrane Recurrent aphthous stomatitis Epidermal growth factor Tumor necrosis factor-α

Necrotising stomatitis as a presenting symptom of HIV

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Open Journal of Stomatology 2011年第4期1卷 168-171页

作者： Gbemisola A. Agbelusi Olutola M. Eweka 不详

Background: Necrotising stomatitis is an uncommon oral infection associated with diminished systemic resistance (immunocompromised state) including HIV infection. Significant predisposing factors include poor oral hygiene, unusual life stress, recent illness (e.g. Measles), malnutrition, smoking and even inade- quate sleep. It occurs commonly in developing na-tions with poor living conditions. Objective: To present a case of severe Necrotising stomatitis in a previously undiagnosed HIV Seropositive patient. Patient and method: This case report describes severe, rapidly spreading necrotising stomatitis in a 35 years old lady, the condition which led to her being diagnosed with HIV. The treatment modalities, challenges of man-agement and the differential diagnosis were discussed. Result: During the course of her management, pa-tient’s oral condition improved. However, later re-currence was seen due to severe anaemia caused by malnutrition and aggravated by Zidovudine antiret-roviral drug. Conclusions: There is need for interdis-ciplinary interactions between the dentists and the physicians managing HIV patients, to allow effective management and afford patient the best treatment.

关键词： Necrotizing stomatitis HIV Anaemia Zidovudine

Adverse Effects of Morphine and Fentanyl for stomatitis in Patients Receiving Allogeneic Hematopoietic Cell Transplantation—A Single Center Retrospective Analysis

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Open Journal of Blood Diseases 2012年第4期2卷 81-84页

作者： Mayuko Koshino Yasushi Okoshi Naoki Kurita Naoshi Obara Kazumi Suzukawa Yuichi Hasegawa Shigeru Chiba Department of Hematology University of Tsukuba Tsukuba Japan Department of Hematology University of Tsukuba Tsukuba Japan.

Opioids are widely used as analgesics for oral mucositis in allogeneic hematopoietic cell transplantation (allo-HCT). Their main adverse events are nausea, vomiting, constipation, psychological symptoms, and respiratory depression. In our institute, continuous intravenous morphine was generally used until 2007, followed by intravenous fentanyl as the first-line agent because of its potential fewer adverse events. We retrospectively analyzed 99 patients who underwent allo-HCT in the University of Tsukuba Hospital from 2004 to 2009. Out of 99 patients, 64 were treated with opioids (morphine, 32 and fentanyl, 32). The attending physicians were in charge of providing stable pain control. Median age, sex, stem cell source, preparative regimen, and GVHD prophylaxis were similar in the two groups. There were no significant differences in psychological symptoms, drowsiness, nausea, and vomiting in both groups. Defecation ratio (the days having a bowel movement/the days taking opioids) was 63% and 94% in the morphine and fentanyl group, respectively (P < 0.0001). The percentage of patients who needed to use purgative drugs was 25% and 6% in the morphine and fentanyl group, respectively (P = 0.04). It is suggested that fentanyl has less adverse effects on gastrointestinal movement and is safer than morphine when used for oral mucositis in allo-HCT.

关键词： stomatitis Morphine Fentanyl Allo-HCT Constipation

A cross-sectional study on oncology nurses' knowledge and practice of oral mucositis among cancer patients in Jordan

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International Journal of Nursing Sciences 2019年第3期6卷 283-287页

作者： Loai Abu Sharour Faculty of Nursing AL-Zaytoonah University of JordanJordan

Objectives: This study was conducted to evaluate oncology nurses' knowledge and compliance with oral mucositis (OM) management guidelines.Methods: A cross-sectional design with a nonparticipant observation approach was utilized.In phase Ⅰ,a cross-sectional convenience sample (n =140) of oncology nurses completed the knowledge test.In phase Ⅱ,a random sample (n =20) of oncology nurses from participants in phase I was observed during their practice.Results: Fifty-seven (40.7%) of the participants had an unsatisfactory level of knowledge.Most of them had knowledge deficits regarding pathology,OM definition,assessment,scoring,treatment,and patient education and advice.A significant difference existed among nurses with diploma,bachelor,and postgraduate degrees as determined by one-way ANOVA (P =0.001).There were no significant difference between average scores of male and female nurses were higher than those of nurses (P=0.45).No significant difference was observed among knowledge scores of nurses with different job titles (P =0.51).The average score of male nurses in terms of skill performance was higher than that of female nurses (29.20 ± 2.10 vs 27.10 ± 1.80) without statistical significance.Conclusion: The knowledge and compliance with OM management guidelines among Jordanian oncology nurses need to be improved.National OM prevention and management guidelines are adopted in Jordan.Continuing education and training are also recommended.

关键词： Jordan Knowledge Medical oncology Nurses Questionnaire stomatitis