卡-梅综合征:干扰素的危险性和应用己酮可可碱的成功治疗

作     者：De La Hunt M.N. 虎小毅 

作者机构：Department of Paediatric Surgery Royal Victoria Infirmary Newcastleupon-Tyne NE1 4LP United Kingdom 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第5期

页      面：48-48页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学] 

主　　题：α-干扰素 卡-梅综合征 己酮可可碱 治疗 血小板减少症 血小板计数 血管畸形 皮质激素 血小板量 

摘      要：A girl aged 3 months presented with thrombocytopenia and bruising around a large vascular malformation of her posterior abdominal wall. Treatment was started with corticosteroids and platelet replacement, but with no improvement and a platelet count persistently less than 10×109/L over 3 weeks, α-interferon was added. There was an immediate increase in bruising, a fall in platelet count, and an increase in platelet transfusion requirement until interferon was discontinued 11 days later. After a further week, the platelet count returned to the levels before interferon, but the patient did not develop any further symptoms. The platelet count remained low with no clinical change until pentoxifylline was start ed at the age of 15 months. The platelet count rose to 117×109/L within 4 days and remai- ned more than 100×109/L thereafter. The patient is now 7 years old and has had no recurrence since stopping the pentoxifylline at the age of 5 years. Although thrombocytopenia is a recognized side effect of interferon therapy, this very dangerous complication has not been previously reported using interferon for the Kasabach-Merritt syndrome.