Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli

作     者：Rongsui Gao Yue Li Jingxia Lin Chen Tan Youjun Feng 

作者机构：Department of Medical Microbiology and Parasitology Zhejiang University School of Medicine State Key Laboratory of Agricultural Microbiology College of Veterinary Medicine Huazhong Agricultural University 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2016年第59卷第7期

页      面：732-734页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars (LR15H190001) the National Natural Science Foundation of China (31570027) the start-up package from Zhejiang University (Youjun Feng) the "Young 1000 Talents" Award (Youjun Feng) 

主　　题：大肠埃希菌 复杂性 耐药 多粘菌素 抗性基因 食品动物 哈斯曼 

摘      要：Dear Editor,The discovery that the mobile colistin resistance gene(mcr-1)is encoded by plasmids and is prevalent in food animals and human beings worldwide(Hasman et al.,2015;Liu et al.,2015)has challenged greatly our traditional idea that polymyxin(consisting of two isoforms:polymyxin B and polymyxin E(colistin))acts as an ultimate line of refuge in the clinical treatment against the severe infections by the multidrug-resistant Gram-negative pathogens(Nation et al.,2015;Paterson and Harris,2015).To make