海洋分枝杆菌对第二代四环素类的不同反应
Mycobacterium marinum with different responses to second-generation tetracyclines作者机构：Department
出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)
年 卷 期：2005年第1卷第9期
页 面：54-55页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：四环素类 分枝杆菌感染 药物治疗方案 米诺环素 接触污染 药动学 多西环素 持续性
摘 要：Background:Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials. Due to the rarity of this infection, there are few data comparing the different treatment alternatives. Methods:We report a patient with culture-proven M. marinum who was treated with two different second-generation tetracyclines. Results:Our patient failed a 4-week trial of doxycycline, but responded rapidly to minocycline. Conclusion:This case suggests that, despite a similar mechanism, pharmacokinetics and even sensitivity, these two agents may differ in their effectiveness against strains of M. marinum.
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