Clinical treatment of myasthenia gravis with deficiency of spleen and kidney based on combination of disease with syndrome theory

作     者：Chao Jiang Ping Liu Yan Liang Shaobo Qiu Wenjing Bao Jingsheng Zhang 

作者机构：Traditional Chinese Medicine Department of Longhua Hospital Affiliated to Shanghai University ofTCM Neurological Medical Department of the Hospital Affiliated to Liaoning University of TCM 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2013年第33卷第4期

页      面：444-448页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：Supported by a Key Project in Basic Research of Shanghai Municipal Committee of Science(No.10JC1414500) a Planned Project in the TCM Fund of Scientific Research under the Shanghai Municipal Health Bureau (2010J002B) 

主　　题：Myasthenia gravis Deficiency of spleen and kidney Jianjining Combination of disease with syndrome 

摘      要：OBJECTIVE: To study the use of Jianjining in the treatment of myasthenia gravis (MG) patients with a deficiency of both spleen and kidney via the theory on the combination of disease with syndrome. METHODS: Sixty MG patients with a deficiency of both spleen and kidney were randomly divided into an treatment group (n=30) treated with Jianjining granules and Western Medicine (prednisone or pyridostigmine bromide) and a control group (n= 30) treated with Jianjining granules. The dosage of the three drugs was reduced over the course of treatment. After 3 and 6 months of treatment, the curative effect was evaluated with the muscle weakness severity scale (MWSS). RESULTS: The MWSS score after treatment declined significantly in both groups. The score in the treatment group was much lower than that in thecontrol group (P0.05) in the obvious and effective rates between the 2 groups. However, the total effective rate in the treatment group was much higher than that in the control group (P0.01). CONCLUSION: Using the theory on the combination of disease with syndrome, we found that the curative effect of Jianjining and Western Medicine on MG patients with deficiency of both spleen and kidney is worth further exploration.