Clinical Utility of the Ratio Between Circulating Fibrinogen and Fibrin （ogen） Degradation Products for Evaluating Coronary Artery Disease in Type 2 Diabetic Patients

作     者：Wei-Xin Xiong Ying Shen Dao-Peng Dai Lin Lu Qi Zhang Rui-Yan Zhang Wei-Feng Shen Rong Tao 

作者机构：Department of Cardiology Ruijin Hospital Jiao Tong University School of Medicine Shanghai 200025 China Institute of Cardiovascular Disease Jiao Tong University School of Medicine Shanqhai 200025 China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2015年第128卷第6期

页      面：727-732页

核心收录：

学科分类：10[医学] 

基　　金：the grants from Chinese Natural Science Foundation Shanghai Science and Technology Key Project 

主　　题：Coronary Artery Disease Diabetes Mellitus Fibrin (ogen) Degradation Products Fibrinogen 

摘      要：Background:We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP)reflects the severity of coronary artery disease (CAD) in type 2 diabetic ***:Plasma levels of Fg and FDP were determined,and Fg/FDP ratio was calculated in 344 consecutive patients with type 2 diabetes and chest pain on exertion undergoing coronary *** severity of CAD was evaluated by the number of significant CAD (50％ luminal diameter narrowing) and Gensini ***:Plasma Fg was higher,but Fg/FDP ratio was lower in patients with significant CAD (n =255) compared with those without (n =89),due to a disproportionate increase in *** and FDP correlated positively,while Fg/FDP ratio negatively,with the number of diseased coronary arteries and the tertile of Gensini score (all P values for trend 0.01).After adjusting for age,sex,risk factors for CAD,lipid profiles,glycosylated hemoglobin A1c,creatinine,leukocyte count,and high-sensitivity C-reactive protein,Fg/FDP ratio remained an independent determinant for multivessel coronary disease (MVD) (odds ratio [OR],0.869; 95％ confidence interval [CI],0.788-0.958,P =0.005) and high tertile of Gensini score (OR,0.797,95％ CI,0.682-0.930,P =0.004).The area under the curve of Fg/FDP ratio was larger than that of Fg for predicting the presence of MVD (0.647 vs.0.563,P =0.048) and Gensini score ≥ 30 (0.656 vs.0.53 8,P =0.026).Conclusions:Elevated plasma Fg and FDP level and reduced Fg/FDP ratio are associated with presence of CAD,and Fg/FDP ratio is superior to Fg in reflecting severe coronary atherosclerosis for patients with type 2 diabetes.