Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency:a Clinical Multidetector Computed Tomography Study

作     者：DENG Min WANG Yi Xiang James F. GRIFFITH LU Gang Anil T AHUJA POON Wai S 

作者机构：Department of Imaging and Interventional Radiology Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China Division of Neurosurgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2012年第25卷第6期

页      面：607-613页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 1001[医学-基础医学(可授医学、理学学位)] 08[工学] 080203[工学-机械设计及理论] 0802[工学-机械工程] 

基　　金：Supported by GRF of Hong Kong SAR (project no. 464508) a direct grant for research from the Chinese University of Hong Kong (project no.2041501) 

主　　题：Bone mineral density Quantitative computed tomography, Rat Vertebra Orchiectomy Ovariectomy Cortical bone Trabecular bone 

摘      要：Objective To investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. Methods Orchiectomized and ovariectomized rat models are used to investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. A rat vertebral body can be longitudinally divided into central portion, which contain more trabecular bone, and para-endplate portions which contain more compact bone. In matured male and female Wistar and Sprague-Dawley rat lumbar spines, we investigated baseline bone mineral density （BMD） characteristics and the differential segmental responses in bone loss within the lumbar vertebral body post gonadal surgery with clinical multidetector computed tomography. Results Para-endplate sections had a higher BMD than central sections. The cephalad para-endplate sections had a higher BMD than the caudad para-endplate sections. Eight weeks after gonadal removal, there was more bone loss in central sections than para-endplate sections. The relative difference of bone loss between para-endplate and central sections was more apparent in male rats than in female rats. There was more bone loss in caudad sections than cephalad sections; this lead to a further increase of BMD difference between caudad para-endplate sections and cephalad para-endplate sections post gonadal surgery. Conclusion The approach described in this study provided a consistent way to study BMD change within predominantly compact bone portion and trabecular bone portion of the vertebral body.