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Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic orchiectomy)

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Journal of Cancer Therapy 2015年第15期6卷 1249-1253页

作者： Manana Alibegashvili Nato Veshapidze Liana Ramishvili Manana Gordeziani Teimuraz Chigogidze Nino Gabunia Ana Khazaradze Nanuli Kotrikadze Department of Biology Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University Tbilisi Georgia Department of Urology Faculty of Medicine Ivane Javakhishvili Tbilisi State University Tbilisi Georgia

The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na+/K+-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na+/K+-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondingly—protective abilities of an organism, which was proved by the anamneses of patients.

关键词： Prostate Tumors Plastic orchiectomy Na+/Ka+-ATP-ase

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Testicular prostheses-impact on quality of life and sexual function

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Asian Journal of Andrology 2024年第2期26卷 160-164页

作者： Ana Sofia Araujo Sara Anacleto Ricardo Rodrigues Catarina Tinoco Andreia Cardoso Carlos Oliveira Ricardo Leao Department of Urology Braga's HospitalBraga 4710Portugal Faculty of Medicine Coimbra UniversityCoimbra 3000Portugal

orchiectomy is the recommended treatment for many testicular ***,testicular prosthesis placement is not always performed for different *** this study,we aimed to evaluate patients'opinions and the impact on sexual function and quality of *** retrospective observational single-center study included patients who underwent orchiectomy between January 2014 and December 2020 at the Department of Urology,Braga's Hospital(Braga,Portugal),where testicular implants were always available and the decision to undergo the procedure was made fully independent of *** completed four questionnaires that assessed demographic data,satisfaction,self-esteem,and sexual *** the 96 patients who underwent orchidectomy,59 replied to the questionnaires,and of these patients,86.4%decided to undergo silicone-based testicular prostheses *** remaining 13.6%refused the implant based on concerns about complications(37.5%),because they felt that it was unnecessary(37.5%),or because it was not offered by the doctor(25.0%).Overall,96.1%of these patients were satisfied with the implant;however,25.5%classified it as"too firm".No statistically significant differences were found in sexual function(all P>0.05).However,it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses(74.0%vs 50.0%),and none of them reported severe erectile dysfunction(0 vs 16.7%).Regarding self-esteem,both patients with and without prostheses present very similar average scores with no statistically significant *** present study highlights the highest level of satisfaction among patients who received testicular *** prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

关键词： orchiectomy patient satisfaction quality of life sexual dysfunction sexual health testicular prostheses

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Long-term follow-up results of testicular torsion in children

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Asian Journal of Andrology 2022年第6期24卷 653-659页

作者： Cheng-Jun Yu Jie Zhao Jin Luo Yi-Fan Hong Tian-Xin Zhao Sheng Wen Li Jiang Tao Lin Da-Wei He Guang-Hui Wei Sheng-De Wu Department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400014China Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering Chongqing 400014China National Clinical Research Center for Child Health and Disorders Chongqing 400014China China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing 400014China Chongqing Key Laboratory of Pediatrics Chongqing Chongqing 400014China Ministry of Education Key Laboratory of Child Development and Disorders Chongqing 400014China Department of Pediatric Urology Guangzhou Women and Children's Medical CenterGuangzhou Medical UniversityGuangzhou 510620China Department of Urology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

December 2020 to investigate the long-term follow-up results after testicular torsion(TT)in *** with TT were divided into the salvage orchiopexy group and the orchiectomy group,and the baseline characteristics,ultrasonographic indications,intraoperative findings,testicular volumes,and adverse events during follow-up were compared.A total of 145 cases were included in this *** 56.6%of patients who underwent salvage orchiopexy had testicular atrophy(TA),and the median testicular volume loss of the testes was 57.4%.Age less than 6 years,delayed surgery,and intraoperative poor blood supply were associated with TA in pediatric TT after *** atrophied testes appeared within 3-6 months after *** with the corresponding age-matched healthy controls,the contralateral testicular volumes were larger in the orchiopexy(P=0.o01 without TA,and P=0.042 with TA)and orchiectomy groups(P=0.033).The adverse events were comparable in patients with orchiectomy or *** summary,follow-up before 3 months after surgery may not offer sufficient clinical value,while that 3 months after surgery should be regarded as the first follow-up time for testicular *** contralateral testes of patients with TT showed compensatory *** suggest performing orchiectomy when torsed testes are surgically assessed as Arda gradeⅢor inviable.

关键词： long-term orchiectomy pediatrics salvage orchiopexy testicular torsion

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Aggressive angiomyxoma of the epididymis: A case report

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World Journal of Clinical Cases 2023年第29期11卷 7214-7220页

作者： Xu-Jie Liu Jia-Hao Su Qi-Zhong Fu Ying Liu Department of Urology Surgery Affiliated Zhongshan Hospital of Dalian UniversityDalian 116001Liaoning ProvinceChina

BACKGROUND Aggressive angiomyolipoma is an extremely rare benign mesenchymal tumor that was originally described as a locally recurrent mucinous spindle cell ***-ressive angiomyolipoma originates from myofibroblasts,vascular smooth muscle cells,or fibroblasts,and displays various phenotypes of myofibroblasts and abnor-mal muscle *** angiomyolipoma was first identified in 1983 and fewer than 50 male patients have been reported to *** is an extremely rare mesenchymal tumour and often confused with other *** with epididymal aggressive angiomyolipoma lack typical symptoms,most of which occur incidentally,although some patients may experience mild pain,discomfort,and *** may be exacerbated by pressure from the *** SUMMARY A 66-year-old male was admitted to the hospital on January 14,2022 with chief complaint of swelling in the left scrotum for one *** was no apparent cause for the *** patient did not consult with any doctor or receive any treatment for the *** enlarged scrotum increased in size gradually until it reached approximately the size of a goose egg,and was accompanied by discom-fort and swelling of the left cavity of the *** patient had no history of any testicular trauma,infection,or urinary tract *** patient urinated freely,1-2 times at night,without urgency,dysuria(painful urination),or *** was no significant family history of *** patient underwent excision of the enlarged tumour and the left epididymis under general anaes-thesia on January 18,*** months of follow-up revealed no *** patient was satisfied with the *** Aggressive angiomyolipoma is extremely rare clinically and often confused with other *** pathogenesis of aggressive angiomyolipoma is unclear and the clinical presentation is mostly a painless enlarged *** diagnosis of aggressive angiomyolipoma requires a combination of medi

关键词： Aggressive angiomyxoma Mesenchymal tumor Scrotal mass Epididymal malignancy orchiectomy Male reproductive system neoplasms Case report

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Ultrasound heterogeneity as an indicator of testicular salvage in testicular torsion: A single center experience

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Asian Journal of Urology 2022年第1期9卷 57-62页

作者： Omran Hasan Mohamed Mubarak S.Mohamed Jawad Alwedaie Hasan Baksh Husain Alaradi Ameer Alarayedh Ali Alaradi Abdolsalam Ahmadi Akbar Jalal Department of Surgery Salmaniya Medical Complex Ringgold Standard InstitutionManamaBahrain

Objective:Testicular torsion is a common urological emergency,mainly in the younger *** aim is to evaluate the efficacy and value of testicular echogenicity in predicting testicular ***:Patients who were older than 13 years of age and were discharged with the diagnosis of testicular torsion were *** obtained included demographic data,history,physical examination results,ultrasound findings including size,color Doppler flow,and echotexture,torsion degrees,and surgical *** addition,the histopathological findings of patients who underwent orchiectomy were ***:A total of 71 cases were diagnosed with testicular torsion between January 2016 to December *** mean age at presentation was 20.4±7.0 *** average time from the onset of pain until the presentation was 36.0±55.1 *** of the 71 ultrasound scans reviewed,45.1%showed homogenous echotexture and 54.9%showed heterogeneous echotexture of the affected *** scrotal exploration,the mean degree of torsion was 475.7±301.8 degrees;66.2%of the patients had a viable testis;and bilateral orchidopexy was *** remaining 33.8%had a non-viable *** echotexture was after an average of 13.5 h of scrotal pain,while heterogeneous echotexture presented after 53.7 h of scrotal *** was a statistically significant difference between the time of presentation and echotexture changes on scrotal ultrasonography(p<0.01).The relationship between echotexture changes and testicular viability was statistically significant as well(p<0.001).Conclusion:A long time since the onset of pain coupled with heterogeneous changes in testicular parenchyma is a good indicator of ***,we still advocate for surgical exploration as the gold standard in diagnosis and management.

关键词： Testis Testicular torsion Orchiopexy orchiectomy Ultrasound Echotexture

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Protein profiles in various epididymal segments of normal and castrated rats

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Asian Journal of Andrology 2000年第1期2卷 57-64页

作者： PremenduP.Mathur AileenMarshall C.Y.Cheng School of Life Sciences Pondicherry University Pondicherry-605 014 India The Population Council Center for Biomedical Research 1230 York Avenue New York NY 10021 USAThe Population Council Center for Biomedical Research 1230 York Avenue New York 10021 USAThe Population Council Center for Biomedical Research 1230 York Avenue New York 10021 USA

Aim: Epididymal proteins are known to play an important role in the maturation of spermatozoa, we ougnt to deter-mine if there are regional differences in androgen-dependent epididymal proteins. Methods: A group of adult rats wascastrated and epididymides were removed three days following castration. The epididymides were dissected into caput,corpus and cauda segments, homogenized, and proteins were fractionated by anion exchange HPLC. Proteins in select-ed fractions were resolved by SDS-PAGE and visualized by silver staining. Results: It was observed that the levels ofmultiple proteins drastically reduced in the various regions of epididymis of the orchiectomized rats. Conclusion: Theepididymal proteins appear to be useful markers to study androgenic action in the epididymis.

关键词： epididymis proteins sperm maturation orchiectomy castration rats

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The modern testicular prosthesis:patient selection and counseling,surgical technique,and outcomes

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Asian Journal of Andrology 2020年第1期22卷 64-69页

作者： Solomon Hayon Jamie Michael R Matthew Coward Department of Urology University of North Carolina School of MedicineChapel HillNC 27500-7235USA University of North Carolina School of Medicine Chapel HillNC 27500-7235USA

The testicular prosthesis can be an afterthought for providers when performing an orchiectomy for testicular cancer,torsion,atrophic testis,or ***,data suggest that patients find the offer of a testicular prosthesis and counseling regarding placement to be extremely important from both a pragmatic and a psychosocial *** two-thirds of men undergoing orchiectomy are offered an implant at the time of orchiectomy and of those offered about one-third move forward with prosthesis *** relatively low acceptance rate is in stark contrast with high patient satisfaction and low complication rates for those who undergo the *** most common postoperative patient concerns are minor and involve implant positioning,size,and ***,we provide an up-to-date review of modern preoperative evaluation,patient selection,expectation management,surgical technique,and expected outcomes for testicular prostheses.

关键词： anorchia orchiectomy patient satisfaction prostheses and implants testicular neoplasms testis

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Characteristics of Rat Lumbar Vertebral Body Bone Mineral Density and Differential Segmental Responses to Sex Hormone Deficiency:a Clinical Multidetector Computed Tomography Study

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Biomedical and Environmental Sciences 2012年第6期25卷 607-613页

作者： DENG Min WANG Yi Xiang James F. GRIFFITH LU Gang Anil T AHUJA POON Wai S Department of Imaging and Interventional Radiology Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China Division of Neurosurgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong Shatin N.T. Hong Kong China

Objective To investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. Methods Orchiectomized and ovariectomized rat models are used to investigate sex hormone deficiency related osteoporosis and efficacy of different therapies. A rat vertebral body can be longitudinally divided into central portion, which contain more trabecular bone, and para-endplate portions which contain more compact bone. In matured male and female Wistar and Sprague-Dawley rat lumbar spines, we investigated baseline bone mineral density （BMD） characteristics and the differential segmental responses in bone loss within the lumbar vertebral body post gonadal surgery with clinical multidetector computed tomography. Results Para-endplate sections had a higher BMD than central sections. The cephalad para-endplate sections had a higher BMD than the caudad para-endplate sections. Eight weeks after gonadal removal, there was more bone loss in central sections than para-endplate sections. The relative difference of bone loss between para-endplate and central sections was more apparent in male rats than in female rats. There was more bone loss in caudad sections than cephalad sections; this lead to a further increase of BMD difference between caudad para-endplate sections and cephalad para-endplate sections post gonadal surgery. Conclusion The approach described in this study provided a consistent way to study BMD change within predominantly compact bone portion and trabecular bone portion of the vertebral body.

关键词： Bone mineral density Quantitative computed tomography, Rat Vertebra orchiectomy Ovariectomy Cortical bone Trabecular bone

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Management of the Torsion of Spermatic Cord in the Urology-Andrology Department of the Ignace Deen National Hospital in Conakry

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Open Journal of Urology 2023年第10期13卷 399-406页

作者： Thierno Mamadou Oury Diallo Mamadou Bissiriou Bah Mamadou Diawo Bah Boris Amougou Daouda Kanté Alimou Diallo Demba Cissé Abdoul Haqq Bah L’Imam Mamadou Dian Oury Diallo Abdoulaye Bobo Diallo Oumar Raphiou Bah Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea Faculty of Medicine and Pharmaceutical Sciences University of Dschang Dschang Cameroon

Introduction: Torsion of the spermatic cord is an emergency whose delay in treatment conditions the functional prognosis of the testicle. The aim of this study was to analyze the management of spermatic cord torsion in the Urology Andrology Department of the Ignace Deen National Hospital in Conakry. Material and methods: This was a ten-year retrospective descriptive study from January 1, 2012 to December 31, 2021. It involved all patients admitted for torsion of the spermatic cord, confirmed at surgical exploration. Results: We identified 21 cases of torsion of the spermatic cord. The mean age of the patients was 17.9 ± 4.4 years. The average consultation time was 19.2 ± 21.4 hours with extremes of [2 h and 98 h]. Only 6 patients (28.6%) consulted before the sixth hour. All patients presented with scrotal swelling. At scrototomy, all torsions were intravaginal with two turns of spiral in 13 cases and three turns in 8 cases. orchiectomy followed by contralateral orchidopexy was performed in 6 cases. In the other cases, bilateral orchidopexy was performed after detorsion. The average hospital stay was 4.5 days. We recorded 4 cases of testicular atrophy after orchidopexy. Conclusion: Spermatic cord torsion is an infrequent emergency in our department. The delay in consultation remains the main predictive factor of testicular necrosis. Emergency exploratory scrotomy should be the rule.

关键词： Spermatic Cord Torsion Delay in Consultation Orchidopexy orchiectomy Testicular Atrophy

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Laparoscopic Management of Undescended Testis: Results and Outcomes in a Pediatric Population

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Open Journal of Pediatrics 2022年第1期12卷 47-58页

作者： C. Kamadjou H. E Moby A. Kameni E. Muhawenimana F. F. Mouafo Tambo F. Angwafor Medical and Surgical Center of Urology Douala Cameroon Faculty of Medicine and Pharmaceutical Sciences Department of Surgery and Specialties University of Douala Douala Came-roon Kigali Teaching Hospital Kigali Rwanda Gynaeco Obstetric and Pediatric Hospital Yaounde Cameroon Urology Residency Program Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon

Aim: This study aimed to evaluate the results of the laparoscopic treatment of high and intra-abdominal undescended testes. Methods: A retrospective study was carried out from 2014 to 2021 at the Centre medico-chirugicale d’urologie in Douala. We consulted the clinical records of 27 patients aged 6 - 15 years who underwent laparoscopic orchiopexy at our hospital. We included patients with unilateral or bilateral undescended testes as detected by palpation and excluded patients with incomplete clinical records. The data collected were entered into Microsoft Excel 2016 and exported to Epi info 7 for analysis. Continuous variables were presented as mean values and standard deviations while categorical variables were presented as frequencies and percentages. The threshold for statistical significance was set at p Results: The ages of the 27 participants ranged from 6 years to 15 years, with a mean age of 10.22 ± 2.68 years. Hypospadias was an associated abnormality in 7.41% of participants. The mean duration of the surgical procedure was 80.56 ± 30.30 minutes. The overall success rate of the laparoscopic procedure was 95.83%. The mean duration of postoperative hospital stay was 26.67 ± 7.69 hours. The only postoperative complication we encountered was testicular atrophy, which occurred in 7.41% of participants. All our patients underwent single-stage laparoscopic procedures. Conclusion: Laparoscopy, which is the technique of choice for the diagnosis and management of undescended testis, is more rapid, more effective, and characterized by a shorter hospital stay and fewer postoperative complications compared to open surgery. Single-stage procedures are as effective and safe as two-stage procedures.

关键词： Undescended Testis Laparoscopy Orchiopexy orchiectomy Single-Stage Procedure

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