Research development of the pathogenesis pathways for neuroschistosomiasis

作     者：王鹏 吴明灿 陈世洁 罗国才 成祥林 朱占胜 赵光锐 

作者机构：长江大学临床医学院外科教研室荆州434000 长江大学附属第一医院神经外科荆州434000 长江大学附属第一医院神经内科荆州434000 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2010年第26卷第2期

页      面：168-174页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Science Foundation of the Department of Health  Hubei Province  China (No. XF06D43  XF2008-23) 

主　　题：schistosome neuroschistosomiasis the central nervous system pathways granuloma pathogenesis 

摘      要：The infection of the central nervous system （CNS） by schistosome may or may not have clinical manifestations. When symptomatic, neuroschistosomiasis （NS） is one of the most severe presentations of schistosome infection. Among the NS symptoms, cerebral invasion is mostly caused by Schistosoma japonicum （S. japonicum）, and the spinal cord symptoms are mainly caused by S. mansoni or S. haematobium. There are 2 main pathways by which schistosomes cause NS： egg embolism and worm migration, via either artery or vein system, especially the valveless perivertebral Batson＇s plexus. The adult worm migrates anomalously through the above pathways to the CNS where they lay eggs. Due to the differences in species of schistosomes and stages of infection, mechanisms vary greatly. The portal hypertension with hepatosplenic schistosomiasis also plays an important role in the pathogenesis. Here the pathways through which NS occurs in the CNS were reviewed.