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Preventive effect of artemether on schistosome infection

Chinese Medical Journal 1998年第2期 27-31页

作者：宋宇肖树华吴伟张绍基谢慧群许雪萍胡新勇崔庆陈名刚郑江

Abstract Objective To study the preventive effect of artemether (Art) in protecting the people from schistosome infection during flood fighting in schistosomiasis endemic area of Poyang Lake, Jiangxi Province. Methods From mid July to mid August in 1996, the water level in Poyang Lake rose due to torrential rains and 2 embankments, Zhedi and Jiangtongdi, which appeared in dangerous situation and were selected as the pilot spots. After those who went to fight against flood arrived at the pilots their sera were collected within 48 hours and were examined with indirect hemagglutination test (IHA), enzyme linked immunosorbent assay (ELISA) and McAb ELISA. Individuals with negative outcome in the 3 tests were then selected as the study subjects and were allocated randomly to the Art or the control group. The first dose of Art given to the individuals contacted with the infested water within 11 15 days was 6 mg/kg. If the individual continually contacted the infested water, the same dose of Art was given once every 15 days. After the individuals withdrew from the pilot, one more dose of Art was administered 7 15 days later. Placebo (starch) was given to individuals in the control group at the same period as in artemether group. Stool examinations were made in both groups 40 50 days after the last medication for evaluation of the preventive effect of artemether. Double blind method was used in the administration of both artemether and placebo. Results In Zhedi pilot, the individuals fought against flood for about 1 month. In Art group, 99 individuals receiving 3 doses of the drug completed the stool examination with egg positive rate of 4% and no acute schistosomiasis was seen. In the control group, among 110 people who completed the observation, 44 were egg positive with an infection rate of 40%, and 29 were identified as having acute schistosomiasis. In Jiangtondi, the studied individuals contacted the infested water for only about 4 hours. But in t

关键词：张绍 effect artemether infection schistosome 吴伟 Preventive

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Genome assembly and transcriptome analysis provide insights into the antischistosome mechanism of Microtus fortis

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Journal of Genetics and Genomics 2020年第12期47卷 743-755页

作者： Hong Li Zhen Wang Shumei Chai Xiong Bai Guohui Ding Yuanyuan Li Junyi Li Qingyu Xiao Benpeng Miao Weili Lin Jie Feng Mingyue Huang Cheng Gao Bin Li Wei Hu Jiaojiao Lin Zhiqiang Fu Jianyun Xie Yixue Li Bio-Med Big Data Center CAS Key Laboratory of Computational BiologyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Veterinary Research Institute Chinese Academy of Agricultural SciencesKey Laboratory of Animal ParasitologyMinistry of AgricultureShanghai 200241China Shanghai Laboratory Animal Research Center Shanghai 201203China Institute for Digital Health International Human Phenome Institutes(Shanghai)Shanghai 200433China Shanghai Center for Bioinformation Technology Shanghai Academy of Science and TechnologyShanghai 201203China School of Computer Science and Technology Harbin Institute of Technology(Shenzhen)ShenzhenGuangdong 518055China Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai JiaoTong University School of MedicineShanghai 200025China State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Contemporary AnthropologyCollaborative Innovation Center for Genetics and DevelopmentSchool of Life SciencesFudan UniversityShanghai 200438China Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhouZhejiang 330106China

Microtus fortis is the only mammalian host that exhibits intrinsic resistance against Schistosoma japonicum ***,the underlying molecular mechanisms of this resistance are not yet ***,we perform the first de novo genome assembly of ***,comprehensive gene annotation analysis,and evolution ***,we compare the recovery rate of schistosomes,pathological changes,and liver transcriptomes between *** and mice at different time points after *** observe that the time and type of immune response in *** are different from those in *** activates immune and inflammatory responses on the 10th day post infection,such as leukocyte extravasation,antibody activation,Fc-gamma receptor-mediated phagocytosis,and the interferon signaling cascade,which play important roles in preventing the development of *** contrast,an intense immune response occurrs in mice at the late stages of infection and could not eliminate *** mice suffer severe pathological injury and continuous decreases in cell cycle,lipid metabolism,and other *** findings offer new insights into the intrinsic resistance mechanism of *** against schistosome *** genome sequence also provides the basis for future studies of other important traits in ***.

关键词： Genome assembly Microtus fortis schistosome Immune Transcriptome

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Gut microbiota in parasite-transmitting gastropods

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Infectious Diseases of Poverty 2023年第6期12卷 1-18页

作者： Peipei Li Jinni Hong Zhanhong Yuan Yun Huang Mingrou Wu Tao Ding Zhongdao Wu Xi Sun Datao Lin Department of Parasitology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouChina Key Laboratory of Tropical Disease Control Ministry of EducationSun Yat-Sen UniversityGuangzhouChina Chinese Atomic Energy Agency Center of Excellence on Nuclear Technology Applications for Insect Control Provincial Engineering Technology Research Center for Diseases-Vectors ControlSun Yat-Sen UniversityGuangzhouChina Department of Traditional Chinese Medicine Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhouChina

Background Gastropoda,the largest class within the phylum Mollusca,houses diverse gut microbiota,and some gastropods serve as intermediate hosts for *** have revealed that gut bacteria in gastropods are associated with various biological aspects,such as growth,immunity and host-parasite ***,we summarize our current knowledge of gastropod gut microbiomes and highlight future research priorities and *** A literature search was undertaken using PubMed,Web of Science and CNKI for the articles on the gut microbiota of gastropods until December 31,*** retrieved a total of 166 articles and identified 73 eligible articles for inclusion in this review based on the inclusion and exclusion *** Our analysis encompassed freshwater,seawater and land snails,with a specific focus on parasite-transmitting *** found that most studies on gastropod gut microbiota have primarily utilized 16S rRNA gene sequencing to analyze microbial composition,rather than employing metagenomic,metatranscriptomic,or metabolomic *** comprehensive review provided an overview of the parasites carried by snail species in the context of gut microbiota *** presented the gut microbial trends,a comprehensive summary of the diversity and composition,influencing factors,and potential functions of gastropod gut ***,we discussed the potential applications,research gaps and future perspectives of gut microbiomes in parasite-transmitting ***,several strategies for enhancing our comprehension of gut microbiomes in snails were also *** This review comprehensively summarizes the current knowledge on the composition,potential function,influencing factors,potential applications,limitations,and challenges of gut microbiomes in gastropods,with a specific emphasis on parasite-transmitting *** findings provide important insights for future studies aiming to understand

关键词： Snail Intermediate host Gut microbiome Potential application Snail-born parasite schistosome Schistosomiasis Angiostrongylus cantonensis Vector

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Inhibitory effects of prostaglandin E₁ on activation of hepatic stellate cells in rabbits with schistosomiasis

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Hepatobiliary & Pancreatic Diseases International 2007年第2期6卷 176-181页

作者： WeiLong Zou Zhen Yang YunJin Zang DongJian Li ZhiPeng Liang ZhongYang Shen Institute of Transplantation General Hospital of the Chinese People's Armed Police Forces Beijing China. wlzouah@***

BACKGROUND: Liver fibrosis is the result of an imbalance between synthesis and degradation of extracellular matrix proteins of the liver. At the cellular and molecular levels, this progressive process is mainly characterized by activation of hepatic stellate cells (HSCs). Schistosoma japonica is one of the most prevalent causes of liver fibrosis in China. It is characterized by hepatocyte damage, inflammation, and chronic parasite egg-induced granuloma formation leading to fibrosis. This study aimed to investigate the inhibitory effects of prostaglandin E1 (PGE1) on activation of HSCs and the alteration of type Ⅰ and Ⅲ collagen in rabbits with schistosomiasis. The study may promote the clinical application of praziquantel and PGE1 as a combined therapy to reverse hepatic fibrosis caused by schistosomiasis. METHODS: Rabbits were percutaneously infected with cercaria of S. japonicum. Seven rabbits were subjected to intravenous injections of PGE1 (2.5 μg/kg daily) from days 60 to 120 after infection. The ultrastructural changes in activated HSCs were observed under transmission electron microscopy. The expression of α-smooth muscle actin (α-SMA) was detected by immunohistochemistry. Fibril-forming collagens were detected by picrosirius staining. RESULTS: Activation of HSCs was a characteristic alteration in schistosome-induced hepatic fibrosis. The expression of contraction-related α-SMA and thecontent of collagens were increased. Exogenous PGE1 markedly inhibited the activation of HSCs and reduced the expression of α-SMA around the hepatic sinusoids (Pschistosome-induced hepatic fibrosis. PGE1 effect

关键词： hepatic fibrosis schistosome hepatic stellate cells prostaglandin E1 fibril-forming collagen

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