Antibiotic resistance and cagA gene correlation:A looming crisis of Helicobacter pylori

作     者：Adnan Khan Amber Farooqui Hamid Manzoor Syed Shakeel Akhtar Muhammad Saeed Quraishy Shahana Urooj Kazmi 

作者机构：Immunology and Infectious Diseases Research LaboratoryDepartment of MicrobiologyUniversity of KarachiUniversity RoadKarachi 75270Pakistan Division of ImmunologyInternational Institute of Infection and ImmunityShantou University Medical College22 Xinling RoadShantouGuangdong 515041China Department of SurgeryCivil HospitalKarachi 74200Pakistan Hamid ManzoorSyed Shakeel AkhtarMuhammad Saeed QuraishyDepartment of MedicineCivil HospitalKarachi 74200Pakistan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第18期

页      面：2245-2252页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The grants of Higher Education Commission of Pakistan and University of Karachi awarded to Adnan Khan 

主　　题：Helicobacter pylori Antibiotic resistance cagA Pakistan Clarithromycin Metronidazole Fluoroquinolones 

摘      要：AIM:To determine antibiotic resistance of Helicobacter pylori(***) in Pakistan and its correlation with host and pathogen associated ***:A total of 178 strains of *** were isolated from gastric biopsies of dyspeptic *** patterns against first and second-line antibiotics were determined and trends of resistance were analyzed in relation to the sampling period,gastric conditions and cagA gene *** effect of cagA gene on the acquisition of resistance was investigated by mutant selection ***:The observations showed that monoresistant strains were prevalent with rates of 89% for metronidazole,36% for clarithromycin,37% for amoxicillin,18.5% for ofloxacin and 12% for ***,clarithromycin resistance was on the rise from 2005 to 2008(32% vs 38%,P = 0.004) and it is significantly observed in non ulcerative dyspeptic patients compared to gastritis,gastric ulcer and duodenal ulcer cases(53% vs 20%,18% and 19%,P = 0.000).On the contrary,metronidazole and ofloxacin resistance were more common in gastritis and gastric ulcer *** analysis and frequencies of resistant mutants in vitro correlated with the absence of cagA gene with metronidazole and ofloxacin ***:The study confirms the alarming levels of antibiotic resistance associated with the degree of gastric inflammation and cagA gene carriage in *** strains.