Synthesis and Relaxation Properties of Lanthanide(Gd ,Yb) Complexeswith Tris Modified DTPA

作     者：魏俊发 卓仁禧 何地平 

作者机构：Department of Chemistry Shaanxi Normal University Xi'an 710062 China Department of Chemistry Wuhan University Wuhan 430072 China 

出 版 物：《Journal of Rare Earths》 (稀土学报（英文版）)

年 卷 期：1999年第17卷第3期

页      面：166-169页

核心收录：

学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

主　　题：rare earths gadolinium ytterbium aminocarboxylate acid tris MRI contrast agent 

摘      要：Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 ***(-1).s(-1) vs. 5.2, 2.8 and 1.7 ***(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.