过去7年用PDT治疗非黑素瘤性皮肤癌的经验

作     者：Baptista J. Martinez C. Leite L. Cochito M. 罗素菊 

作者机构：Dermatology DepartmentHospital do DesterroRua Nova do Desterro1169-100 LisbonPortugal 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第10期

页      面：8-9页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：黑素瘤 PDT治疗 光敏性药物 皮损数目 Bowen 癌前病变 活性氧 氨基乙酰丙酸 原卟啉 光化性 

摘      要：Background:Topical photodynamic therapy(PDT)with 5-aminolevulinic acid(ALA)was first described by Kennedy et al.in 1990;currently,accumulated evidence shows that topical PDT is effective in the treatment of actinic keratoses,Bowen’s disease and superficial basal cell carcinoma,being potentially advantageous where size,anatomical location or number of lesions limit the efficacy and/or the acceptability of conventional therapies.It involves the use of photosensitizing drugs and the administration of an appropriate light source to activate the sensitizing agent,which leads to the production of activated oxygen species for tissue destruction.The topically administered prodrug 5-ALA is converted within cells into the active photosensitizer protoporphyrin IX,via haem cycle,with preferential accumulation in tumour cells.Methods:The authors describe their experience with topical PDT,using 20%5-ALA and two different incoherent light sources,’Waldman 1200 L’and ’VersaLightTM’,in the treatment of non-melanoma skin cancer and precursor lesions.More than 100 patients were treated since 1997,with up to a 7-year follow-up period.Results:Cases are illustrated and results are presented and discussed in the light of the relevant Literature.Conclusion:The study suggests that 5-ALA PDT is effective in the treatment of superficial skin cancer and premalignant lesions.