Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults(south-east of Iran)

作     者：A Jafarzadeh MT Rezayati M Nemati 

作者机构：Department of Immunology Medical School Rafsanjan University of Medical Sciences Rafsanjan Iran 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第22期

页      面：3117-3121页

核心收录：

学科分类：100208[医学-临床检验诊断学] 1002[医学-临床医学] 10[医学] 

主　　题：伊朗 幽门螺杆菌 儿童 成年人 血清免疫球蛋白G 免疫保护力 抗体 

摘      要：AIM: To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS: Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS: The seroprevalence of H pylori in adults was signif icantly higher than that observed in children (67.5/ vs 46.6/; P 0.000003). In children, the seropositivity rate in males (51.9/) was signifi cantly (P 0.05) higher than that observed in females (41.7/). The prevalence of serum anti-CagA antibody was 72.8/ and 67.4/ in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4/ vs 66.3/; P = 0.07 and 75.6/ vs 54.71/; P 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6/ and 59.57/ at age 1-5 years, 46.9/ and 75/ at age 6-10 years, 54.9/ and 79.45/ at age 11-15, 59.01/ and 83.33/ at age 20-30 years, 66.6/ and 60.52/ at age 31-40 years, 73.46/ and 63.88/ at age 41-50 years and 75.75/ and 60/ at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P 0.001). CONCLUSION: These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori-specifi c antibodies influenced by age and sex of subjects. Moreover, it seems that malesare more susceptible to infection with CagA+ strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.