Development of a hybrid scaffold and a bioreactor for cartilage regeneration

作     者：LEE Seung-Jae LEE In Hwan PARK Jeong Hun GWAK So-Jung RHIE Jong-Won CHO Dong-Woo KO Tae Jo KIM Dong Sung 

作者机构：BK21 Mechatronics Group at Chungnam National University School of Mechanical Engineering Chungbuk National University DDS Research Lab.CKD Research Institute CKD Pharmaceutical Corp. Department of Plastic Surgery College of Medicine The Catholic University of Korea Department of Mechanical Engineering Pohang University of Science and Technology School of Mechanical Engineering Yeungnam University School of Mechanical EngineeringChung-Ang University 

出 版 物：《Chinese Science Bulletin》 (CHINESE SCIENCE BULLETIN)

年 卷 期：2009年第54卷第19期

页      面：3608-3612页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：Supported by the Korea Science and Engineering Foundation (Grant No. R01-2008-000-20568-0) Center for Nanoscale Mechatronics & Manufacturing and 21st Century Frontier Research Programs of Ministry of Education Science and Technology Korea 

主　　题：MTT 生物分解 凝解胶 研究 

摘      要：We developed a hybrid scaffold and a bioreactor for cartilage regeneration. The hybrid scaffold was developed as combination of two components: a biodegradable framework and hydrogel-containing chondrocytes. We performed the MTT cell proliferation assay to compare the proliferation and viability of chondrocytes on three types of scaffolds: an alginate gel, the hybrid scaffold, and an alginate sponge. Cells were encapsulated in 2% agarose gel. The bioreactor consisted of a circulation system and a compression system. We performed dynamic cell culture on these agarose gels in the bioreactor for 3 days.