含芳基磷脂酰胆碱类似物的合成

作     者：黄雁 Picq,M 

作者机构：广州医学院化学教研室广州510182 

出 版 物：《应用化学》 (Chinese Journal of Applied Chemistry)

年 卷 期：1999年第16卷第5期

页      面：88-90页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：0 

主　　题：磷脂酰胆碱 磷脂类似物 合成 酰化 

摘      要：The acylation reactions of L α Lysophosphatidylcholine(Lyso PC) or L α *** 2(GPC CdCl 2) with fatty acid bearing bulky aromatic group or corresponding anhydride have been investigated. The acylation of Lyso PC with fatty acid bearing bulky aromatic group in the presence of condensing reagent N,N ′ dicyclohexylcarbodiimide(DCC) and catalyst 4 ( N,N ′ dimethylamino) pyridine(DMAP) was found to be more convenient and more efficient than that of Lyso PC with the corresponding fatty acid anhydride prepared prior to acylation(yield 85% to 45%). The poor formation of anhydride from fatty acid is responsible largely for the low yield. It was found that the acylation reaction of Lyso PC or GPC CdCl 2 with fatty acid bearing bulky aromatic group could be accomplished in 85% and 74% yield respectively by using a fatty acid/Lyso PC(or GPC CdCl 2) molar ratio of 4, DMAP/Lyso PC(or GPC CdCl 2) molar ratio of 4 and DCC/fatty acid molar ratio of 0 6 (1 for the acylation of GPC CdCl 2). The procedures described provide significant improvements in yield over methods repor ted .