Protein induced by vitamin K absence or antagonist Ⅱ-producing gastric cancer
Protein induced by vitamin K absence or antagonist Ⅱ-producing gastric cancer作者机构：Department of PathologyTeikyo University School of Medicine Department of PathologyTokyo Kousei-Nenkin Hospital
出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)
年 卷 期：2010年第1卷第4期
页 面：129-136页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Protein induced by vitamin K absence or antagonist Ⅱ Gastric cancer Alpha-fetoprotein Hepato-cellular carcinoma Hepatoid carcinoma
摘 要：Protein induced by vitamin K absence or antagonist Ⅱ(PIVKA-Ⅱ) is a putative specific marker of hepatocellular carcinoma(HCC),but it may also be produced by asmall number of gastric *** date,16 cases of PIVKA-Ⅱ-producing gastric cancer have been reported,2 of which were reported by us and all of which were identified in *** are no symptoms specific to PIVKA-Ⅱ-producing gastric cancer,and the representative clinical symptoms are general fatigue,appetite loss,and upper abdominal *** alpha-feto-protein(AFP)levels are also increased in almost *** metastasis is observed in approximately 80% of cases and portal vein tumor thrombus is ob-served in approximately 20% of *** diagnosis between metastatic liver tumor and HCC is often ***,almost all cases appear as advanced gastric ***,a hepatoid pattern is observed in many cases,in addition to a moderately to poorly differentiated adenocarcinoma *** production of PIVKA-Ⅱ and AFP is usually confirmed using immunohistochemical *** and prognosis largely depends on the existence of liver meta-stasis,and the prognosis of patients with liver metas-tasis is very ***-Ⅱ may be produced during the hepatocellular metaplasia of the tumor cells.
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