Protein-only" or "virino" in prion diseases?

作     者：YANG Chiming (Chi Ming Yang) & CHEN Yi1. Institute for Life Science and Health at UCSD, P.O.Box 12035, La Jolla, CA 92039, USA 2. Institute of Chemistry, Academy of Sciences, Beijing 100080, China Correspondence should be addressed to Yang Chiming 

作者机构：Institute for Life Science and Health at UCSD La Jolla USA Institute of Chemistry Academy of Sciences Beijing China 

出 版 物：《Chinese Science Bulletin》 (CHINESE SCIENCE BULLETIN)

年 卷 期：2000年第45卷第3期

页      面：285-288页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

基　　金：加利福尼亚WynneZhao神经科研项目 王宽诚教育基金 

主　　题：prions mad cow disease neurodegenerative disorder subviral pathogen prion radical. 

摘      要：60-year prion and scrapie research has led to a dilemma in understanding the unknown aetiology of the infectious neurodegenerative disorders with intriguing features. Current progress and dilemma in prion research are briefly but critically reviewed. Instead of providing a comprehensive coverage of the research history, attentions in this view are drawn toward both the major breakthrough in the advancement of protein-only hypothesis, and the puzzle why this hypothesis has not been fully accepted. In order to resolve the prion enigma in neuroscience, it is suggested that both technical and concept barriers remain to be crossed. Since prion research is a multi-interdisciplinary subject, this view is intended to both facilitate a bette r understanding of prion phenomenon by more scientists in natural science, and invite scientists outside the fields of molecular genetics and protein science for collaboration.