Gelatin-Based Metamaterial Hydrogel Films with High Conformality for Ultra-Soft Tissue Monitoring

作     者：Yuewei Chen Yanyan Zhou Zihe Hu Weiying Lu Zhuang Li Ning Gao Nian Liu Yuanrong Li Jing He Qing Gao Zhijian Xie Jiachun Li Yong He Yuewei Chen;Yanyan Zhou;Zihe Hu;Weiying Lu;Zhuang Li;Ning Gao;Nian Liu;Yuanrong Li;Jing He;Qing Gao;Zhijian Xie;Jiachun Li;Yong He

作者机构：State Key Laboratory of Fluid Power and Mechatronic SystemsSchool of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China School of Mechanical EngineeringGuizhou UniversityGuiyang 550025People’s Republic of China Stomatology HospitalSchool of StomatologyZhejiang University School of MedicineClinical Research Center for Oral Diseases of Zhejiang ProvinceKey Laboratory of Oral Biomedical Research of Zhejiang ProvinceCancer Center of Zhejiang UniversityHangzhou 310006People’s Republic of China 

出 版 物：《Nano-Micro Letters》 (纳微快报（英文版）)

年 卷 期：2024年第16卷第2期

页      面：347-364页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：This work was sponsored by the National Natural Science Foundation of China(No.52235007,52325504) the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(No.T2121004) 

主　　题：Implantable hydrogel-based bioelectronics Conformality 3D printing Metamaterial design 

摘      要：Implantable hydrogel-based bioelectronics(IHB)can precisely monitor human health and diagnose ***,achieving biodegradability,biocompatibility,and high conformality with soft tissues poses significant challenges for *** is the most suitable candidate for IHB since it is a collagen hydrolysate and a substantial part of the extracellular matrix found naturally in most *** study used 3D printing ultrafine fiber networks with metamaterial design to embed into ultra-low elastic modulus hydrogel to create a novel gelatin-based conductive film(GCF)with mechanical *** regulation of GCF nearly covers soft tissue mechanics,an elastic modulus from 20 to 420 kPa,and a Poisson’s ratio from-0.25 to *** negative Poisson’s ratio promotes conformality with soft tissues to improve the efficiency of biological *** GCF can monitor heartbeat signals and respiratory rate by determining cardiac deformation due to its high ***,the gelatin characteristics of the biodegradable GCF enable the sensor to monitor and support tissue *** GCF metamaterial design offers a unique idea for bioelectronics to develop implantable sensors that integrate monitoring and tissue repair and a customized method for endowing implanted sensors to be highly conformal with soft tissues.