0.1%他扎罗汀软膏和赋形剂对光老化皮肤组织学的作用:对面部光老化皮肤患者的6月周期、多中心、双盲、随机、赋形剂对照研究

作     者：Machtinger L.A. Kaidbey K. Lim J. J. Sefton 牛新武 

作者机构：AllerganInc.ClinicalRes earchandDevelopment2525Dupont Drive Irvine CA 92612 United States 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2005年第1卷第5期

页      面：17-18页

学科分类：1002[医学-临床医学] 10[医学] 100206[医学-皮肤病与性病学] 

主　　题：光老化 他扎罗汀 皮肤组织学 角质形成细胞 黑素细胞 赋形 表皮水肿 颗粒层 异型性 色素沉着 

摘      要：Background:Topical tazarotene has been shown to offer efficacy in amelioratin g multiple effects of photodamage. Objectives To evaluate the histological effec ts of tazarotene cream on photodamaged skin. Methods:In this multicentre, doubl e-blind, randomized, vehicle-controlled study, 50 patients with photodamaged f acial skin (at least mild fine wrinkling and mottled hyperpigmentation, with at least one of these being moderate) were randomized to apply tazarotene 0.1%crea m or vehicle cream to their face, once daily for 24 weeks. Results:Blinded asse ssments showed that tazarotene was less likely than vehicle to be associated wit h an increase in keratinocytic and melanocytic atypia, and more likely than vehi cle to be associated with a reduction in atypia. Between-group comparisons in d istribution of change from baseline categories of severity were in favour of taz arotene (P=0.055 for keratinocytic atypia, P= 0.034 for melanocytic atypia, and P 0.001 for the number of granular cell layers). Compared with vehicle, tazaro tene was associatedwithanincreaseinepidermalpolarity(P=0.008)and epidermalthickn ess(P=0.012),and a tendency for stratum corneum compaction,Tazarotene was also a ssociated with widened intercellular spaces (reported as epidermal oede ma) relative to vehicle (P 0.001). Conclusions:Treatment of photodamaged sk in with tazarotene is associated with an amelioration of keratinocytic and melan ocytic atypia, an improvement in epidermal polarity, and an increase in epiderma l thickness.