检索结果-南通市图书馆

Suofu Qin’s work on studies of cell survival signaling in cancer and epithelial cells

World Journal of Biological Chemistry 2010年第12期1卷 369-376页

作者： Suofu Qin, Retinal Disease Research, Department of Biological Sciences, allergan, Inc., 2525 Dupont Drive, Irvine, CA 92612-1599, United States Suofu Qin Retinal Disease Research Department of Biological Sciences Allergan Inc. 2525 Dupont Drive Irvine CA 92612-1599 United States.

Reactive oxygen species (ROS) encompass a variety of diverse chemical species including superoxide anions, hydrogen peroxide, hydroxyl radicals and peroxynitrite, which are mainly produced via mitochondrial oxidative metabolism, enzymatic reactions, and light-initiated lipid peroxidation. Over-production of ROS and/or decrease in the antioxidant capacity cause cells to undergo oxi- dative stress that damages cellular macromolecules such as proteins, lipids, and DNA. Oxidative stress is associated with ageing and the development of agerelated diseases such as cancer and age-related macular degeneration. ROS activate signaling pathways that promote cell survival or lead to cell death, depending on the source and site of ROS production, the specific ROS generated, the concentration and kinetics of ROS generation, and the cell types being challenged. However, how the nature and compartmentalization of ROS contribute to the pathogenesis of individual diseases is poorly understood. Consequently, it is crucial to gain a comprehensive understanding of the molecular bases of cell oxidative stress signaling, which will then provide novel therapeutic opportunities to interfere with disease progression via targeting specific signaling pathways.Currently, Dr. Qin's work is focused on inflammatory and oxidative stress responses using the retinal pigment epithelial (RPE) cells as a model. The study of RPE cell inflammatory and oxidative stress responses has successfully led to a better understanding of RPE cell biology and identification of potential therapeutic targets.

关键词： Cancer Inflammation Oxidative stress Retinal pigment epithelial cells Signal transduction Therapeutic target

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

透明质酸填充剂HYC-24/HYC-24+治疗中国中、重度鼻唇沟皱褶患者满意度的真实世界研究

引用

中华整形外科杂志 2024年第4期40卷 436-443页

作者：曹令宋为民徐士亮隋志甫 Joy Maglambayan Vaishali Patel 北京丽都医疗美容医院整形外科北京100101 杭州颜术悦容医疗美容诊所美容皮肤科杭州州310008 广州粤秀整形外科医院整形外科广州1510600 allergan Aesthetics(艾伯维旗下公司) 新加坡117439 allerganAesthetics(艾伯维旗下公司) 美国加利福尼亚州尔湾市92612

目的评估中国中度至重度鼻唇沟皱褶(NLF)患者在真实的临床实践环境中接受HYC-24/HYC-24+治疗后的结局满意度。方法本研究是一项前瞻性、观察性、多中心、真实世界队列研究。纳入2018年8月至2020年8月于北京丽都医疗美容医院、杭州颜术... 详细信息

目的评估中国中度至重度鼻唇沟皱褶(NLF)患者在真实的临床实践环境中接受HYC-24/HYC-24+治疗后的结局满意度。方法本研究是一项前瞻性、观察性、多中心、真实世界队列研究。纳入2018年8月至2020年8月于北京丽都医疗美容医院、杭州颜术悦容医疗美容诊所和广州粤秀整形外科医院接受HYC-24/HYC-24+治疗,并随访长达1年的中国患者,年龄18至65岁、患有中度至重度NLF,且在研究入组前6个月内未接受过NLF的美容治疗。在第1、6、9和12个月进行治疗后研究访视,仅第6个月和第9个月为必须进行的访视。患者报告结局的主要终点包括:FACE-Q结局满意度问卷总分(评分范围为0~100分,分数越高表示结局越好,患者越满意),FACE-Q皱纹评估-NLF问卷总分较基线的平均变化(评分范围为0~100分,评分越高表示患者在过去1周内越不受到NLF的困扰),以及在FACE-Q患者感知年龄视觉模拟评分法(VAS)上报告比实际年龄看起来更年轻的患者比例。研究者评估终点包括整体美容效果改善量表(GAIS)评分≥1分的患者比例,以及使用鼻唇沟皱褶严重程度量表(NLFSS)评估NLF严重程度改善≥1分的患者比例。使用SAS 9.4软件进行统计分析,计量资料采用±s表示,计数资料用例数(%)表示,不同访视时间与基线的比较,采用Wilcoxon符号秩检验。结果共52例患者入组并接受治疗,其中,7例因访视时间超出访视评估窗而未被纳入第6个月有效性的分析数据集,仅9例患者完成了第12个月的访视。所有患者均为中国籍女性,年龄26~62岁,平均为40.7岁。FACE-Q结局满意度问卷总分第6个月时为(68.76±21.03)分(38~100分),第9个月时为(65.44±18.24)分(24~100分),表明患者对治疗的满意度较高。FACE-Q皱纹评估-NLF问卷总分基线时为(42.4±15.1)分(10~69分),第6个月时为(76.9±20.6)分(36~100分),第9个月时为(74.2±16.7)分(36~100分),均较基线得分明显升高(P均<0.01),第6个月和第9个月时问卷总分较基线的平均变化分别为34.9分和31.8分,表明治疗后NLF造成的困扰较轻。FACE-Q患者感知年龄VAS报告认为比实际年龄看起来更年轻的患者比例从基线时的28.9%(15/52)分别增加到第6个月的77.8%(35/45)和第9个月的73.1%(38/52),与基线相比,差异均有统计学意义(P<0.01)。在每次基线后访视时,所有患者的GAIS量表得分改善均≥1分,表明研究者认为患者NLF外观均有所改善。在NLFSS评价方面,分别有97.8%(44/45)和82.7%(43/52)的患者在第6个月和第9个月的NLFSS改善程度≥1分。试验期间无不良事件报告。结论在真实临床实践环境中,对中国患者施用HYC-24/HYC-24+后,使用经验证的问卷调查显示,患者对结局表示满意。患者还报告称治疗后看起来比实际年龄年轻,并且受NLF的困扰较少。临床医生报告结局与患者报告结局一致,表明NLF有所改善。

关键词：鼻唇沟,鼻唇褶透明质酸患者满意度亚裔整形手术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EP4 agonist alleviates indomethacin-induced gastric lesions and promotes chronic gastric ulcer healing

引用

World Journal of Gastroenterology 2009年第41期15卷 5149-5156页

作者： Wha Bin Im Yariv Donde Larry A Wheeler Department of Biological Sciences and Medical Chemistry Herbert Research Center Allergan Inc. Irvine California CA 92612 United States

AIM: To investigate EP4-selective agonist effect on indomethacin-induced gastric lesions and on the spontaneous healing of chronic gastric ulcers.METHODS: In a mouse model of gastric bleeding with high dose of indomethacin (20 mg/kg), an EP4-selective agonist was administered orally. Stomach lesions and gastric mucous regeneration were monitored. In a mouse model of chronic gastric ulcer induced by acetic acid, EP4 agonist effect on the healing of chronic gastric ulcer was evaluated in the presence or absence of low dose indomethacin (3 mg/kg). In cultured human gastric mucous cells, EP4 agonist effect on indomethacin-induced apoptosis was assessed by ? ow cytometry.RESULTS: The EP4-selective agonist reduced high dose indomethacin-induced acute hemorrhagic damage and promoted mucous epithelial regeneration. Low-dose indomethacin aggravated ulcer bleeding and inflammation, and delayed the healing of the established chronic gastric ulcer. The EP4 agonist, when applied locally, not only offset indomethacin-induced gastric bleeding and inflammation, but also accelerated ulcer healing. In the absence of indomethacin, the EP4 agonist even accelerated chronic gastric ulcer healing and suppressed inflammatory cell infiltration in the granulation tissue. In vitro, the EP4 agonist protected human gastric mucous cells from indomethacininduced apoptosis.CONCLUSION: EP4-selective agonist may prevent indomethacin-induced gastric lesions and promote healing of existing and indomethacin-aggravated gastric ulcers, via promoting proliferation and survival of mucous epithelial cells.

关键词：受体激动剂胃溃疡膜损伤消炎痛愈合慢性

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bimatoprost/timolol fixed combination(BTFC) in patients with primary open angle glaucoma or ocular hypertension in Greece

引用

International Journal of Ophthalmology(English edition) 2016年第1期9卷 69-75页

作者： Tryfon G.Rotsos Vasso G.Kliafa Kevin J.Asher Dimitrios Papaconstantinou 1st Department of Ophthalmology University of Athens Department of Regulatory Affairs Nexus Medicals S.A. Department of Regional Scientific Services Allergan Holdings Limited

AIM：To evaluate the efficacy and tolerability of the fixed combination of bimatoprost 0.03%and timolol 0.5%（BTFC）in patients in Greece with primary open angle glaucoma（POAG）or ocular hypertension（OHT）whose previous therapy provided insufficient lowering of intraocular pressure（IOP）.·METHODS：A multicenter,prospective,open-label,non-interventional,observational study of the use of BTFC in clinical practice was conducted at 41 sites in Greece.The primary endpoint was the reduction in IOP from baseline at study end,approximately 12wk after initiation of BTFC therapy.·RESULTS：A total of 785 eligible patients were enrolled in the study and 97.6%completed the study.The mean±SD IOP reduction from baseline at 12wk after initiation of BTFC was 6.3±2.8 mm Hg（=764;〈0.001）.In patients（=680）who replaced their previous IOP-lowering monotherapy（a single drug,or a fixed combination of 2drugs in a single ophthalmic drop）with once-daily BTFC,the mean±SD IOP reduction from baseline at 12wk was 6.2±2.8 mm Hg（〈0.001）.IOP was reduced from baseline in 99.2%of patients,and 58.0%of patients reached or exceeded their target IOP.Substantial mean IOP reductions were observed regardless of the previous therapy.BTFC was well tolerated,with 96.0%of patients who completed the study rating the tolerability of BTFC as＂good＂or＂very good.＂Adverse events were reported in 8.3%of patients;only 0.6%of patients discontinued the study due to adverse events.·C ONCLUSION：In clinical practice in Greece,BTFC is well tolerated and effectively lower the IOP in patients with POAG or OHT who requires additional IOP lowering on their previous therapy.

关键词： fixed combination glaucoma intraocularpressure ocular hypertension primary open angle glaucoma prostaglandin prostamide timolol

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NEUROPROTECTIVE EFFECT OF MEMAN- TINE IN DIFFERENT GANGLION CELL INJURY MODELS

引用

国际眼科杂志 2003年第1期3卷 17-18页

作者： L.A.Wheeler E.WoldeMussie G.Ruiz allergan Inc. CA USAAllergan Inc. CA USAAllergan Inc. CA USA

Purpose: Memantine, an uncompetitive NMDA receptor channel blocker has been used in the treatment of Parkinson’s disease and dementia. This study was done to evaluate the neu-roprotective effeet of memantine in different retinal ganglion cell (RGC) injury models in rats. Methods: Neuroprotective effect of memantine was tested in calibrated optic nerve

关键词：神经节细胞损伤模型视网膜美金刚神经保护作用 NNDA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A 3-MONTH RANDOMIZED CONTROLLED TRIAL OF BIMATOPROST (LUMIGAN) VERSUS TIMOLOL/DORZOLAMIDE (COS - OPT) IN PATIENTS WITH GLAUCOMA OR OCULAR HYPERTENSION A. Coleman, P. Bern-

引用

国际眼科杂志 2003年第1期3卷 27-28页

作者： A.Coleman P.Bern-stein S.Whitcup Jules Stein Institute/UCLA CAAllergan Inc. CA USAAllergan Inc. CA USA

Objective: To compare efficacy and safety of bimato-prost (Lumigan) QD vs timolol/dorzolamide (Cosopt) BID. Methods: Randomized, double-masked, multicenter 3-month clinical trial. 177 patients with glaucoma or ocular hypertension with uncontrolled intraocular pressure (IOPs between 22 and 34 mmHg) after at least 2 weeks of timolol 0.5% monotherapy

关键词：青光眼高眼压治疗 Bimatoprost 噻吗洛尔/多佐胺随机对照试验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bibliometric analysis of glaucoma-related literature based on SCIE database:a 10-year literature analysis from 2009 to 2018

引用

International Journal of Ophthalmology(English edition) 2020年第12期13卷 1998-2006页

作者： Yun-Xiao Sun Ying-Na Liu Ying Han Fan-Qi Kong Yue Zhang Siloka Arthur Labisi Kai Cao Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Department of Ophthalmology University of California San FranciscoSan FranciscoCA 94143USA allergan plc ShanghaiChina

AIM:To explore the global trends and focus of glaucoma research from 2009 to 2018.METHODS:Searching for glaucoma-related articles published in Science Citation Index Expanded(SCIE)database during 2009-2018,and describing the distribution of the published year,countries,authors,institutions,funding agencies,journals,impact factor,citation and hot research topic of articles by using bibliometric methods.Meanwhile,we compared some of these indicators over two five-year periods,from 2009 to 2013 and from 2014 to 2018.RESULTS:A total of 19609 glaucoma-related articles were retrieved and the global SCIE articles have increased yearly from 2009 to 2018.The USA was the pioneer which has made great contributions.China kept the second place and the number of publications has increased rapidly between 2014 and 2018.The author with the highest number of publications was Weinreb,RN.Co-occurrence maps were built amongst the top 50 authors or the top 50 institutions with the most articles,which visualize the closer collaboration of international authors or institutions.The journal Investigative Ophthalmology&Visual Science has published the most papers.Glaucoma literature with an impact factor of 3-5 points accounted for the largest proportion(28.96%).The most frequently cited paper had 798 citations.The top three hot areas on glaucoma were intraocular pressure,optical coherence tomography(OCT)and retinal ganglion cells.And trabecular meshwork,primary angle-closure glaucoma and Spectral-domain OCT have become new hot research topics in recent five years during 2014-2018.CONCLUSION:Bibliometric analysis is an effective method to describe the global literature on glaucoma.In a 10-year literature survey from 2009 to 2018,global glaucoma research has developed in a balanced manner,and the cooperation between various institutions and teams has become closer.Glaucoma-related pathogenesis research,imaging examinations of OCT and surgery therapy have attracted most attention.

关键词： bibliometric analysis Science Citation Index Expanded glaucoma ocular hypertension

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ocular toxicity and advances in its detection

Ocular toxicity and advances in its detection

引用

中国毒理学会第六届全国毒理学大会

作者： Edward CHOW DABT Allergan

＜正＞Vision loss is among the most dreadful chronic handicaps for most people.Ocular toxicity is an important potential cause of vision loss besides ocular injuries and diseases.Ocular toxicity is known to be caused by a wide variety of agents including industrial chemicals（eg,acids/alkalis,oxidi- zing agents,and alcohols）,environmental chemicals（eg,lead,methylmercury,and pesticides）,pharmaceuticals （eg,steroids and anticholinergics）,and even herbal medicines（eg,canthaxanthine and ginkgo biloba）,and is therefore a very important area for toxicologists.As a result of diligent screening, most chemicals that can cause severe acute ocular effects have either been eliminated from industrial and commercial usage or are tightly controlled for proper use.However,subtler ocular effects that are not easily detectable in acute ocular screening assays can lead to eventual significant vision deficits.Fortunately, the eye is a uniquely transparent organ that allows for easy access and modern technological advances now enable us to evaluate ocular structure and function in both the anterior and posterior chambers of the eye through non-invasive means.For the anterior chamber,common assessments now include slit-lamp biomicroscopy,pachymetry,tonometry,and specular microscopy.For the posterior chamber,available techniques include indirect ophthalmoscopy,electroretinograhy,and spectral domain optical coherence tomography.These endpoints of interest and agents which can alter the endpoint will be discussed along with the strengths and limitations of these tools as illustrated by specific examples.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Application of nonclinical assays in screening drug candidates for hepatotoxicity

Application of nonclinical assays in screening drug candidat...

引用

中国毒理学会第九次全国毒理学大会

作者： Edward Chow William Chang Josh Rowe allergan PLC

＜正＞More than 900 drugs have been implicated in causing liver injury, and it is not surprising that hepatotoxicity is the most frequent single cause of safety-related drug marketing withdrawals over the last few decades. Tremendous effort has been made over the last decade to improve the understanding of the mechanisms underlying drug induced hepatotoxicity, including both the idiosyncratic type(causing

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

DIFFERENTIAL RESPONSES TO BIMATO- PROST AND PGF2ALPHA IN CAT IRIS SPHINCTER CELLS SUGGEST THE IN-OLVEMENT OF DIFFERENT RECEPTORS

引用

国际眼科杂志 2003年第1期3卷 103-104页

作者： A.H.P.Krauss C.S.Spada D.F.Woodward A.L.Nieves L.A.Wheeler D.Scott G.Sachs allergan Inc. Irvine CAVeterans Administration Hospital CA USA

Bimatoprost (LUMIGAN) is a novel synthetic prostamide that potently lowers intraocular pressure in dogs, primates and humans. Bimatoprost is functionally and pharmacologically distinct from PGF2alpha, potently exhibits prostamide-like activities and works directly to lower IOP. In this series of studies, confocal fluorescence microscopy was employed to compare the effects

关键词： Bimatoprost PGF2α 猫瞳孔括约肌细胞药效受体

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：