Beyond familial risk: deriving risk-adapted starting ages of screening among people with a family history of colorectal cancer
作者机构：Division of Clinical Epidemiology and Aging Research German Cancer Research Center (DKFZ) Heidelberg Germany Medical Faculty Heidelberg Heidelberg University Heidelberg Germany Division of Preventive Oncology German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg Germany German Cancer Consortium (DKTK) German Cancer Research Center (DKFZ) Heidelberg Germany
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2023年第43卷第12期
页 面：1377-1380页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported in part by grants from the German Cancer Aid(Deutsche Krebshilfe,grants no.70113330 and 70114735) the German Federal Ministry of Education and Research(grant no.01KD2104A)
摘 要：Dear Editor,Colorectal cancer(CRC)is the third most common cancer globally[1],even though a large proportion of those cancers would be preventable by *** those with a family history(FH)of CRC,it is commonly recommended to start screening at younger ages,e.g.,at age 40 or 10 years younger than the age at diagnosis of the youngest affected first-degree relative[2–5].Even within the group of those with a FH,risk of CRC is not homogeneous and depends on factors such as the number of affected relatives and the age at which the relatives were diagnosed with CRC[6,7],lifestyles,and genetic background ***,these metrics except genetic factors may change over lifetime,which limits their use for defining starting ages of *** aim of this study was to evaluate whether a polygenic risk score(PRS),which combines information from CRC-related risk variants[8]and genetically determined sex(2 constant and established CRC risk factors),could effectively contribute to enhanced risk *** also aimed to determine if it could assist in defining risk-adapted starting ages for CRC screening,even in individuals with a FH of *** assessment was performed using the wellestablished metric of risk advancement periods(RAPs)[9],which measures the impact of an exposure on the relation of age to disease.
维普期刊数据库