Nitric Oxide-Releasing Poly(L-glutamic acid)Hybrid Hydrogels for Accelerating Diabetic Wound Healing
作者机构：Schoolof Chemistry and Chemical EngineeringFrontiers Science Centerfor Transformative MoleculesShanghai Key Laboratory o Electrical Insulation and Thermal AgingShanghai Jiao Tong UniversityShanghai 200240China Department of Environmental HealthSchoolof Public HealthShanxi Medical UniversityTaiyuanShanxi 030012China
出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)
年 卷 期：2023年第41卷第17期
页 面：2103-2112页
核心收录：
学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学]
基 金：financial support by National Natural Science Foundation of China(22075176) Natural Science Foundation of Shanghai(22ZR1429200)
主 题：Polypeptide Hydrogel Nitric oxide Diabetic wound Wound healing Wound dressings
摘 要：Comprehensive Summary,Diabetic wound healing is threatening worldwide and challenging in wound *** to inhibit heavy inflammation and bacterial infection in diabetic wounds,herein,we facilely construct a kind of NO-releasing poly(L-glutamic acid)(PGA)based graphene oxide(GO)hybrid hydrogel of HDGS at a lower solid percentage,presenting large microporous size of about 20μm,mild photothermal conversion property,and good *** improving hemostasis performance,the less amount of GO endowed the hydrogel with near infrared(NIR)responsivity to control fast and pulsatile NO release for killing bacteria and inhibiting heavy inflammation to proheal diabetic wound,in which a broad spectrum of antibacterial activities toward killing ***,*** and MRSA was achieved via a combined effect of photothermia and NO *** vivo effective hemostasis was attained in a rat liver bleeding model with short hemostatic time of~20 s and lower blood loss of 1.5%—2.0%.Moreover,the treatment of HDGS plus 4 times of mild NIR irradiation(10 min,808 nm,1 W/cm^(2)per time)performed superior full diabetic wound healing within 11—14 d,in which the regenerated skins were characteristic of thick epidermis/dermis,dense blood vessels,some hair follicles-embedding,and high level of collagens.
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