Magnesium metal and its corrosion products:Promising materials for tumor interventional therapy

作     者：Binghui Xu Yuna Song Kairan Yang Yichen Li Bendong Chen Xia Liao Qingan Jia 

作者机构：Xi'an Key Laboratory of Stem Cell and Regenerative MedicineInstitute of Medical ResearchNorthwestern Polytechnical UniversityXi’an 710038China Shaanxi Provincial Key Laboratory of Infection and Immune DiseaseShaanxi Provincial People's HospitalXi’an 710038China School of Marine Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710038China Department of Hepatobiliary SurgeryGeneral HospitalNingxia Medical UniversityYinchuan 750001China Department of NutritionFirst Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710038China Institute of Medical ResearchNorthwestern Polytechnical University127 West Youyi RoadXi’an 710072China 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2023年第11卷第3期

页      面：763-775页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 0806[工学-冶金工程] 08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Open Funds for Shaanxi Provincial Key Laboratory of Infection and Immune Diseases(2022-KFZD-1) Natural Science Basic Research Program of Shaanxi(2021JM-080,2022JQ-832) the National Natural Science Foundation of China(82203047) 

主　　题：Magnesium Hydrogen gas Mg(OH)_(2) Mg^(2+) Cancer Interventional therapy 

摘      要：Magnesium is generally known to degrade in aqueous environments by an electrochemical *** corrosion products of magnesium include hydrogen gas,Mg^(2+),and Mg(OH)_(2).Here,we summarize the published literature describing the corrosion characteristics of magnesium,and the antitumor properties of magnesium-associated corrosion products,aiming to induce the therapeutic properties of magnesium and magnesium alloys in solid *** therapeutic potential of corrosion products of magnesium is *** gas exhibits antioxidant and anti-inflammatory properties,which amount to potential anti-tumor ***(OH)_(2),which creates a localized alkaline microenvironment,represents a second approach for anti-tumor therapy with magnesium *** concentrations of Mg^(2+)ions in the local tumor microenvironment remodelling are considered a third approach for anti-tumor ***,we speculate about the different physical forms of magnesium that could create an anti-tumor microenvironment upon tumor interventional therapy,a technique that precisely places anti-tumor implants like particles and ***,we present our viewpoints on the potential use of magnesium in diverse solid tumor therapies to inhibit tumor progression.