Integrated gradient tissue-engineered osteochondral scaffolds:Challenges,current efforts and future perspectives

作     者：Xiaolian Niu Ning Li Zhipo Du Xiaoming Li 

作者机构：Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of OrthopedicsThe Fourth Central Hospital of Baoding CityBaoding072350China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第20卷第2期

页      面：574-597页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：support from the National Natural Science Foundation of China(No.32171345) Hebei Provincial Natural Science Foundation of China(No.C2022104003) the Fok Ying Tung Education Foundation(No.141039) the Fund of Key Laboratory of Advanced Materials of Ministry of Education,the International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China the 111 Project(No.B13003) 

主　　题：Osteochondral tissue engineering Integrated gradient tissue-engineered osteochondral scaffold(IGTEOS) Tissue-engineered strategies Fabrication techniques Evaluation 

摘      要：The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as *** engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by constructing integrated gradient tissue-engineered osteochondral scaffold(IGTEOS).This review brought forward the main challenges of establishing a satisfactory IGTEOS from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue,and the limitations of obtaining the desired and required ***,we comprehensively discussed and summarized the current tissue-engineered efforts to resolve the above challenges,including architecture strategies,fabrication techniques and in vitro/in vivo evaluation methods of the ***,we highlighted the advantages and limitations of various fabrication techniques of IGTEOS,and common cases of IGTEOS ***,based on the above challenges and current research progress,we analyzed in details the future perspectives of tissue-engineered osteochondral construct,so as to achieve the perfect reconstruction of the cartilaginous and osseous layers of osteochondral tissue *** comprehensive and instructive review could provide deep insights into our current understanding of IGTEOS.