Progress towards dog-mediated rabies elimination in PR China:a scoping review

作     者：Tianren Shen Susan Christina Welburn Long Sun Guo-Jing Yang Tianren Shen;Susan Christina Welburn;Long Sun;Guo-Jing Yang

作者机构：Key Laboratory of Tropical Translational Medicine of Ministry of EducationThe School of Tropical MedicineThe First Affiliated HospitalHainan Medical UniversityHaikou571199HainanPeople’s Republic of China Zhejiang University-University of Edinburgh Joint InstituteZhejiang UniversityInternational Campus718 East Haizhou RoadHaining314400People’s Republic of China Infection MedicineDeanery of Biomedical SciencesEdinburgh Medical SchoolCollege of Medicine and Veterinary MedicineThe University of Edinburgh1 George SquareEdinburghEH89JZScotlandUK Department of Infectious DiseasesThe First Affiliated Hospital of Hainan Medical UniversityHainan Medical UniversityHaikouHainanPeople’s Republic of China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2023年第12卷第2期

页      面：19-35页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：GY is grateful to the National Natural Science Foundation(Grant no.82260655) Hainan Provincial Natural Science Foundation(Grant no.821CXTD440) the Open Foundation of Key Laboratory of Tropical Translational Medicine of Ministry of Education(ZDKJ202003) Hainan Medical University,as well as National Key Research and Development Program of China(No.2021YFC2300800,2021YFC2300804). 

主　　题：Rabies Lyssavirus China Elimination Dog Epidemics One Health Neglected Tropical Underreporting 

摘      要：Background Rabies continues to be a serious threat to global public health endangering people’s health and public health safety.In the People’s Republic of China,multi-sectoral and comprehensive prevention and control strategies have aimed to extensively curb human rabies transmission.Here,we examine the current state of rabies infection in China,explore strategic interventions put in place in response to WHO’s ambition of“Zero rabies deaths by 2030and critically assess the constraints and feasibility of dog-mediated rabies elimination in China.Methods This study analyzed and evaluated the process towards dog-mediated rabies elimination in China from five perspectives:namely,human,dog,policy,challenge,and prospects.Evidence-based data on progress of dog-mediated rabies elimination in China was derived from a number of sources;a literature search was undertaken using PubMed,Web of Science and CNKI databases,distribution data for human rabies cases as derived from the Data-center of the China Public Health Science and policy and document data were obtained from official websites of the relevant China ministries and commissions.Results The incidence of human rabies cases in China have shown a downward trend year-on-year since 2007.Implementation of a government-led,multi-sectoral“One Healthapproach to combating rabies has driven down the total number of rabies deaths nationwide to around 200 in 2020.The number of provincial-level administrative divisions(PLADs)reporting human cases of rabies has also decreased to 21 in 2020,13 of which reported less than 10 cases.Furthermore,the number of outpatient visits seeking rabies post-exposure prophylaxis has risen dramatically over the past two decades,with demand being 15 times higher than it was initially.There remain however,significant gaps in rabies elimination outcomes across the different regions of China.To date the target of achieving a canine rabies vaccination rate of75%has not been met.The challenges of rabies immunization of dogs and dog management in underdeveloped cities and rural areas need to be addressed together with more effective animal surveillance and rabies risk from and too wildlife and livestock.Conclusions The Chinese government-led,multi-sectoral“One Healthapproach to combating rabies and has made significant progress over the past decade.Development and adoption of more cost-effective One Health strategies can achieve more nationally beneficial rabies elimination outcomes.The ambitious target of“Zero rabies deaths by 2030can be met through establishment of long-lasting herd immunity in dogs by means of dog mass vaccination campaigns,dog population management,epidemiological surveillance and the application of large-scale oral rabies vaccine to eliminate rabies in wild animals coupled with deployment of cost-effective human post-exposure prophylaxis,and community education.