Chronic cola drinking induces metabolic and cardiac alterations in rats
Chronic cola drinking induces metabolic and cardiac alterations in rats作者机构：Instituto de Investigaciones Cardiológicas University of Buenos Aires CONICET Division of Cardiology University of Perugia School of Medicine
出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)
年 卷 期：2011年第3卷第4期
页 面：111-116页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学]
基 金：Supported by Partly Consejo de Investigaciones Científicasy Técnicas (CONICET), and funds from ININCA (UBA) Presented in part at the 20th European Meeting on Hypertension, Oslo,June 17-21, 2010, Norway
主 题：Cola beverages Echocardiography Metabolic syndrome Soft drinks
摘 要：AIM: To investigate the effects of chronic drinking of cola beverages on metabolic and echocardiographic parameters in rats. METHODS: Forty-eight male Wistar rats were divided in 3 groups and allowed to drink regular cola (C), diet cola (L), or tap water (W) ad libitum during 6 mo. After this period, 50% of the animals in each group were euthanized. The remaining rats drank tap water ad libitum for an additional 6 mo and were then sacrificed. Rat weight, food, and beverage consumption were measured regularly. Biochemical, echocardiographic and systolic blood pressure data were obtained at baseline, and at 6 mo (treatment) and 12 mo (washout). A complete histopathology study was performed after sacrifice. RESULTS: After 6 mo, C rats had increased body weight (+7%, P 0.01), increased liquid consumption (+69%, P 0.001), and decreased food intake (-31%, P 0.001). C rats showed mild hyperglycemia and hypertriglyceridemia. Normoglycemia (+69%, P 0.01) and sustained hypertriglyceridemia (+69%, P 0.01) were observed in C after washout. Both cola beverages induced an increase in left ventricular diastolic diameter (C: +9%, L: +7%, P 0.05 vs W) and volumes (diastolic C: +26%, L: +22%, P 0.01 vs W; systolic C: +24%, L: +24%, P 0.05 vs W) and reduction of relative posterior wall thickness (C: -8%, L: -10%, P 0.05 vs W). Cardiac output tended to increase (C: +25%, P 0.05 vs W; L: +17%, not significant vs W). Heart rate was not affected. Pathology findings were scarce, related to aging rather than treatment. CONCLUSION: This experimental model may prove useful to investigate the consequences of high consumption of soft drinks.
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