Antibody seropositivity and endemicity of chikungunya and Zika viruses in Nigeria
作者机构：Institute of VirologyUniversity Medical FreiburgHermann Herder Str1179104 FreiburgGermany World Health OrganizationSpecial Programme for Research and Training in Tropical Diseases(TDR)Avenue Appia 201211 Geneva 27Switzerland World Health OrganizationWHO/NTD UnitAvenue Appia 201211 Geneva 27Switzerland Maldives National UniversityBuruzuMaguMaleMaldives Ethiopian Institute Of Agricultural Research/EIARAddis AbabaEthiopia Icon Clinical ResearchHeinrich‑Hertz Starsse 2663225 Langen HessenBerlinGermany Federal Ministry of HealthNational Tuberculosis and Leprosy ControlProgrammeAbujaNigeria Centre for Medicine and SocietyFaculty of MedicineUniversity of FreiburgFreiburgGermany
出 版 物：《Animal Diseases》 (动物疾病（英文）)
年 卷 期：2023年第3卷第2期
页 面：104-114页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：WHO/NTD:Grant Number:1013487-0
主 题：Chikungunya Zika Cocirculation Seroprevalence Nigeria Endemicity Malaria
摘 要：Mosquito-borne infections are of global health concern because of their rapid spread and upsurge,which creates a risk for *** virus(CHIKV),an arbovirus disease transmitted by Aedes aegypti or ***,and malaria,a parasitic disease transmitted by Anopheles gambiae,are prevalent in Nigeria and neighbouring countries,but their burden and possible coinfections are poorly *** this study,we investigated the antibody seropositivity and endemicity of chikungunya and Zika viruses(ZIKV)in three regions of Nigeria.A cross-sectional serosurvey was conducted on 871 *** were collected from outpatients by simple random *** of the samples were performed using recomLine Tropical Fever for the presence of antibody serological marker IgG immunoblot with CHIKV VLP(virus like particle),ZIKV NS1 and ZIKV Equad according to manufacturers’instructions and malaria RDT for malaria *** was a significantly higher antibody seropositivity against CHIKV in the central region than in the northern and southern regions(69.5%,291/419),while ZIKV-seropositivity(22.4%,34/152)and CHIKV-ZIKV co-circulating antibody seropositivity(17.8%,27/152)were notably higher in the southern region than in the central and northern *** investigation revealed an unexpectedly high antibody seropositivity and concealed endemicity of CHIKV and ZIKV in three Nigerian *** seropositivity of detectable antibodies differed among the three geographical locations.
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