Biointerface engineering of self-protective bionic nanomissiles for targeted synergistic chemotherapy

作     者：Xueyan Zhen Linhao Li Lanlan Jia Aihong Zhu Yixuan Yang Sicen Wang Xiaoyu Xie Xueyan Zhen;Linhao Li;Lanlan Jia;Aihong Zhu;Yixuan Yang;Sicen Wang;Xiaoyu Xie

作者机构：School of PharmacyHealth Science CenterXi’an Jiaotong UniversityXi’an 710061China Shaanxi Engineering Research Center of Cardiovascular Drugs Screening&AnalysisXi’an 710061China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第4期

页      面：116-121页

核心收录：

学科分类：07[理学] 08[工学] 070205[理学-凝聚态物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (Nos. 82073807 and 81973277) the WorldClass Universities (Disciplines) the Characteristic Development Guidance Funds for the Central Universities,China (No. PY3A012) 

主　　题：Aptamer Self-protective Biointerface Targeted drug delivery Synergistic chemotherapy 

摘      要：Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor ***, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.