吸入麻醉药增加β淀粉样蛋白的寡聚化反应和细胞毒性
Inhaled Anesthetic Enhancement of Amyloid-β oligomerization and Cytotoxicity作者机构：Professor Departments of Anesthesia and Physiology Associate Professor Departments of Anesthesia and Biochemis- try/Biophysics and the Johnson Foundation University of Pennsylvania Philadelphia Pennsylvania. Assistant Professor Researeh Scien- tist Department of Anesthesia Assistant Professor Research Fellow Department of Anesthesia Assistant Professor Research Specialist Department of Anesthesia Assistant Professor Research Technician Depament of Anesthesia Assistant Professor Research Associate Department of Anesthesia Assistant Professor Research Scientist Department of Anesthesia 徐州医学院江苏省麻醉举重点实验室
出 版 物：《国外医学（麻醉学与复苏分册）》 (Foreign Medical Sciences(Anesthesilolgy and Resuscitation))
年 卷 期：2004年第25卷第5期
页 面：320-320,i001,i002页
学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学]
基 金：Supported by the Austin Lamont Endowment, Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania from the National Institutes of Health, Bethesda, Maryland(GM55876)
主 题：吸入麻醉药 β淀粉样蛋白 细胞毒性 外科病人 功能障碍 神经变性疾病 老年病人 作者 卤代烃 反应
摘 要：背景:多数外科病人都接受过吸入麻醉药,主要是小分子卤代烃和卤代醚类.长期任知功能障碍发生于麻醉和手术后的老年病人.对神经变性疾病如阿尔茨海默病和帕金森病病人来说,以前接受过手术可能也一个是危险诱发因素.作者认为吸入麻醉药可能通过增强肽的持久寡聚化诱发上述疾病.
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