Flexibility analysis for continuous ibuprofen manufacturing processes

作     者：Wenhui Yang Haoyu Yin Zhihong Yuan Bingzhen Chen Wenhui Yang;Haoyu Yin;Zhihong Yuan;Bingzhen Chen

作者机构：State Key Laboratory of Chemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China School of Material Science and EngineeringTsinghua UniversityBeijing 100084China Department of Chemical EngineeringTsinghua UniversityBeijing 100084China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2022年第51卷第11期

页      面：115-125页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：the financial support from the National Key Research and Development Program of China(2018AAA0101602) 

主　　题：Continuous manufacturing Pharmaceuticals Mathematical modeling Flexibility analysis Mixed integer programing Optimization 

摘      要：Continuous ibuprofen(a widespread used analgesic drug)manufacturing is full of superiorities and is a fertile field both in industry and academia since it can not only effectively treat rheumatic and other chronic and painful diseases,but also shows great potential in dental *** one of central elements of operability analysis,flexibility analysis is in charge of the quantitative assessment of the capability to guarantee the feasible operation in face of variations on uncertain *** this paper,we focus on the flexibility index calculation for the continuous ibuprofen manufacturing *** update existing state-of-the-art formulations,which traditionally lead to the max-max-max optimization problem,to approach the calculation of the flexibility index with a favorable *** regarding the size of the mathematical model and the computational CPU time of the modified method are examined by four *** addition to identifying the flexibility index without any consideration of control variables,we also investigate the effects of different combinations of control variables on the flexibility property to reveal the benefits from taking recourse actions into *** from systematic investigations are expected to provide a solid basis for the further control system design and optimal operation of continuous ibuprofen manufacturing.