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Recent advances and applications of single atom catalysts based electrochemical sensors

Nano Research 2024年第4期17卷 2994-3013页

作者： Mingyue Wang Mingfu Ye Jieyue Wang Yong Xu Zhendong Wang Xinyue Tong Xinya Han Kui Zhang Wenhai Wang Konglin Wu Xianwen Wei Institute of Clean Energy and Advanced Nanocatalysis(iClean) School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China Anhui International Research Center of Energy materials green manufacturing and biotechnology School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Carbon Cycle and Emission Control Research Center Low-Carbon Research InstituteAnhui University of TechnologyMaanshan 243002China

Single atom catalysts(SACs)have attracted considerable attention due to their unique structures and excellent catalytic performance,especially in the area of catalysis science and energy conversion and storage.In recent years,SACs have emerged as a new type of sensing material for constructing electrochemical sensors(ECSs),presenting excellent sensitivity,selectivity,and stability.Herein,we review the recent advances of SACs in electrochemical sensing and discuss the status quo of current SAC-based ECSs.Specifically,the fundamentals of SAC-based ECSs are outlined,including the involved central metal atoms and various supports of SACs in this field,the detection mechanisms,and improving strategies of SAC-based ECSs.Moreover,the important applications of SAC-based ECSs are listed and classified,covering the detection of reactive oxygen and nitrogen species,environmental pollutants,disease biomarkers,and pharmaceuticals.Last,based on abundant reported cases,the current conundrums of SAC-based ECSs are summarized,and the prediction of their future developing trends is also put forward.

关键词： single atom catalysts(SACs) electrochemical sensors(ECSs) reactive oxygen and nitrogen species environmental pollutants disease biomarkers pharmaceuticals

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Evaluation of Phytochemical Contents and Antimicrobial Activities of Pandiaka heudelotii

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Advances in Biological Chemistry 2024年第2期14卷 55-63页

作者： Ikenna Obiora Alaekwe Uche Eunice Ekpunobi Vincent Ishmel Egbulefu Ajiwe Chinedu Chris Aguoma Jamilu Ahmad Department of Chemistry Federal University Gusau Gusau Nigeria Department of Pure and Industrial Chemistry Nnamdi Azikiwe University Awka Awka Nigeria

The work investigated the secondary metabolites present in different parts of the Pandiaka heudelotii plant harvested from Ezira, Orumba south local government area of Anambra state, southeastern Nigeria as well as their antimicrobial activity. The objectives were to extract, determine the phytochemicals present, evaluate the antimicrobial potential and determine the zones of inhibition of the root, stem and leaf extracts of the plant. The emergence of antibiotics has decreased the spread and severity of a wide range of diseases. Plant extracts were tested for antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Streptococcus pyogenes, Bacillus subtelis, Pseudomonas aerogenes, Salmonella typhi, Aspergillus flavus, Aspergillus niger and Candida albicans. The zone of inhibition of extracts was compared with that of standard drugs like Erythromycin, Ciprofloxacin, Fulcin and Fluconazole. The result revealed the inhibition of bacterial and fungal growth with some test organisms. The microbial activity of the plant parts may be due to the presence of various secondary metabolites. The ethyl acetate extracts of Pandiaka heudelotii stood out with a minimum inhibitory concentration (MIC) range of 5 - 10 mg/mL and a minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC) of 10 - 20 mg/ml against some test organisms. The plant can thus be worked upon to discover biologically active natural products that may serve as a prelude to the development of new pharmaceutical research undertakings.

关键词： pharmaceuticals Secondary Metabolites Antibiotics Pandiaka heudelotii Bacteria

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Fate,transport,and risk assessment of widely prescribed pharmaceuticals in terrestrial and aquatic systems:A review

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Emerging Contaminants 2022年第1期8卷 216-228页

作者： Jamal F.Shaheen Banu Sizirici Ibrahim Yildiz Department of Civil Infrastructure and Environmental Engineering Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates Department of Chemistry Khalifa University of Science and TechnologyP.O.Box 127788Abu DhabiUnited Arab Emirates

Rapid development of pharmaceuticals outpaces the efforts to regulate and monitor their trace concentrations in the environment.This emerging issue can only be solved through field studies,solid fate and transport models,and adequate risk assessment of the concerned contaminants.This approach requires the availability of toxicological information about the contaminants along with an understanding of their full potential in different media of the environment.This review paper focuses on commonly used seven pharmaceutical families across the globe:antacids,antibiotics,antidepressants,antiepileptics,beta blockers,lipid lowering drugs,and nonsteroidal anti-inflammatory drugs.Within each family,pharmaceuticals which are widely prescribed,studied,and frequently detected in environment were selected.The concentration levels in the environment,updated physicochemical properties,main natural removal mechanism,and ecological risk assessment towards the receptors of those pharmaceuticals in aquatic and terrestrial systems were analyzed.The following results were observed in the literature:1)removal of the pharmaceuticals from wastewater treatment plants is reduced when the dissolved organic matter present;2)many studies have cited older physicochemical properties of the concerned pharmaceuticals assuming relative conditions in their studies which can affect the accuracy of a model;3)the number of studies are very limited for fate and transport in the soil;and 4)there is lack of cumulative risk assessment of mixed pharmaceutical substances.Therefore,this review will provide modeler with updated physiochemical properties;it will guide researchers to focus on removal of those contaminants at different lifecycle stages;and it will provide guidance to policy makers to develop effective policies and regulations.

关键词： Emerging contaminants pharmaceuticals Fate and transport Risk assessment Removal mechanism

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Hollow fiber-based liquid phase microextraction followed by analytical instrumental techniques for quantitative analysis of heavy metal ions and pharmaceuticals

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Journal of Pharmaceutical Analysis 2020年第2期10卷 109-122页

作者： Wajid Ali Khan Muhammad Balal Arain Yadollah Yamini Nasrullah Shah Tasneem Gul Kazi Stig Pedersen-Bjergaard Mohammad Tajik Department of Chemistry Abdul Wali Khan University Mardan23200KPKPakistan Department of Chemistry University of Karachi75270KarachiPakistan Department of Chemistry Tarbiat Modares UniversityP.O.Box 14115-175TehranIran National Center of Excellence in Analytical Chemistry University of SindhJamshoro76080SindhPakistan School of Pharmacy University of OsloOsloNorway

Hollow-fiber liquid-phase microextraction(HF-LPME)and electromembrane extraction(EME)are miniaturized extraction techniques,and have been coupled with various analytical instruments for trace analysis of heavy metals,drugs and other organic compounds,in recent years.HF-LPME and EME provide high selectivity,efficient sample cleanup and enrichment,and reduce the consumption of organic sol-vents to a few micro-liters per sample.HF-LPME and EME are compatible with different analytical in-struments for chromatography,electrophoresis,atomic spectroscopy,mass spectrometry,and electrochemical detection.HF-LPME and EME have gained significant popularity during the recent years.This review focuses on hollow fiber based techniques(especially HF-LPME and EME)of heavy metals and pharmaceuticals(published 2017 to May 2019),and their combinations with atomic spectroscopy,UV-VIS spectrophotometry,high performance liquid chromatography,gas chromatography,capillary elec-trophoresis,and voltammetry.

关键词： Hollow fiber liquid phase microextraction Electromembrane extraction Heavy metals pharmaceuticals Instrumental techniques

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Analytical methods for determination of terbinafine hydrochloride in pharmaceuticals and biological materials

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Journal of Pharmaceutical Analysis 2016年第3期6卷 137-149页

作者： Basavaiah Kanakapura Vamsi Krishna Penmatsa Department of Chemistry University of Mysore Manasagangotri Mysore 570006 Karnotaka India

Terbinafine is a new powerful antifungal agent indicated for both oral and topical treatment of myco- sessince. It is highly effective in the treatment of determatomycoses. The chemical and pharmaceutical analysis of the drug requires effective analytical methods for quality control and pharmacodynamic and pharmacokinetic studies. Ever since it was introduced as an effective antifungal agent, many methods have been developed and validated for its assay in pharmaceuticals and biological materials. This article reviews the various methods reported during the last 25 years.

关键词： Terbinafine hydrochloride Analytical methods pharmaceuticals Biological materials

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Probing the degradation of pharmaceuticals in urine using MFC and studying their removal efficiency by UPLC-MS/MS

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Journal of Pharmaceutical Analysis 2021年第3期11卷 320-329页

作者： Priya Sharma Devendra Kumar Srikanth Mutnuri Applied Environmental Biotechnology Laboratory Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Central Sophisticated Instrumentation Facility Birla Institute of Technology&Science(BITS)Pilani403726ZuarinagarIndia Department of Pharmaceutical Sciences College of PharmacyUniversity of Nebraska Medical CenterOmahaNE68198-602USA

Nutrient recovery from source-separated human urine has attracted interest as it is rich in nitrogen and phosphorus that can be utilized as fertilizer.However,urine also contains pharmaceuticals,steroid hormones,etc.and their removal is crucial as they have detrimental effects on the environment and human health.The current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell(MFC).Urine was spiked with four pharmaceuticals(trimethoprim,lamivudine,levofloxacin,and estrone)at a concentration of 2 mg/mL.The MFC was operated for 7 months in batch mode with this spiked urine as feed.The degradation efficiency of the MFC was studied,for which a selective liquid chromatography-tandem mass-spectrometric method was developed for the quantitation of compounds used in the spiking experiments and was validated with a lower limit of quantification of 0.39 ng/mL.The maximum removal rate achieved was 96%±2%.The degradation mechanism involved processes like sorption and anoxic biodegradation.The voltage curve obtained showed that the presence of pharmaceuticals had an initial negative impact on power generation along with increased organic content;however,after the reactor acclimatization,increased power output was achieved with maximum organics removal at 30 h of retention time.This work opens a new perspective for the anoxic biodegradation of pharmaceuticals and can be useful in future bioremediation studies.

关键词： pharmaceuticals Urine MFC Biodegradation Liquid chromatography mass spectroscopy

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Occurrence,removal,and environmental risks of pharmaceuticals in wastewater treatment plants in south China

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Frontiers of Environmental Science & Engineering 2018年第6期12卷 69-79页

作者： Huang Huang Jie Wu Jian Ye Tingjin Ye Jia Deng Yongmei Liang Wei Liu School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Guangzhou 510006China Foshan Water Group Co. Ltd.Foshan 528000China

Five pharmaceuticals were detected in wastewater treatment plants in southern China. Biological treatment was the most effective process for PhACs removal. Metoprolol showed negative removal during secondary treatment... 详细信息

关键词： pharmaceuticals Wastewater treatment Pearl River Delta Occurrence Removal Risk assessment

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Determination of 27 pharmaceuticals and personal care products(PPCPs)in water:The benefit of isotope dilution

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Frontiers of Environmental Science & Engineering 2020年第1期14卷 127-136页

作者： Xueqi Fan Jie Gao Wenchao Li Jun Huang Gang Yu State Key Joint Laboratory of Environment Simulation and Pollution Control(SKJLESPC) Beijing Key Laboratory for Emerging Organic Contaminants Control(BKLEOC)School of EnvironmentTsinghua UniversityBeijing 100084China CSD IDEA(Beijing)Environment Test&Analysis Co. Ltd.Beijing 100192China

pharmaceuticals and personal care products(PPCPs)are a unique group of emerging and nonpersistent contaminants.In this study,27 PPCPs in various water samples were extracted by solid phase extraction(SPE),and determined by isotope dilution method using liquid chromatography coupled to tandem triple quadruple mass spectrometer(LC-MS/MS).A total of 27 isotopically labeled standards(ILSs)were applied to correct the concentration of PPCPs in spiked ultrapure water,drinking water,river,effluent and influent sewage.The corrected recoveries were 73%-122%with the relative standard deviation(RSD)<16%,except for acetaminophen.The matrix effect for all kinds of water samples was<22%and the method quantitation limits(MQLs)were 0.45-8.6 ng/L.The developed method was successfully applied on environmental water samples.The SPE extracts of spiked ultrapure water,drinking water,river and wastewater effluent were stored for 70 days,and the ILSscorrected recoveries of 27 PPCPs were obtained to evaluate the correction ability of ILSs in the presence of variety interferences.The recoveries of 27 PPCPs over 70 days were within the scope of 72%-140%with the recovery variation<37%in all cases.The isotope dilution method seems to be of benefit when the extract has to be stored for long time before the instrument analysis.

关键词： pharmaceuticals and personal care products(PPCPs) Isotopically labeled standard(ILSs) Water Solid-phase extraction(SPE) LC-MS/MS

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Multistage defense response of microalgae exposed to pharmaceuticals in wastewater

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Chinese Chemical Letters 2023年第4期34卷 424-429页

作者： Yuhao Chu Chaofan Zhang Xi Chen Xue Li Nanqi Ren Shih-Hsin Ho State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

Recently, the use of microalgae for bioremediation of pharmaceuticals(Ph As) has attracted increasing interest. However, most studies focused more on microalgae removal performance, its defensive response to the Ph As during wastewater treatment remains unexplored. Herein, microalgal three defensive systems have been investigated in synthetic wastewater, with six Ph As as the typical drug. Results show that Ph As could bind to EPS, and this action in turn could help to alleviate the direct toxicity of Ph As to microalgae. Subsequently, the physiological analyses revealed the increase of superoxide dismutase(SOD), catalase(CAT), and peroxidase(POD) activities, potentially reducing the oxidative stress induced by Ph As. Furthermore, the enzyme activities of cytochrome P450(CYP450) and glutathione-S-transferase(GST) were significantly upregulated after exposure to SMX, CIP and BPA, followed by a significant decrease in biodegradation rates after the addition of CYP450 inhibitors, suggesting that the biotransformation and detoxification of Ph As occurred. Meanwhile, molecular docking further revealed that CYP450 could bind with Ph As via hydrogen bond and hydrophobic interaction, which proved their abilities to be metabolized and form transformation products in microalgae. These findings provide an advancing understanding of microalgae technologies to improve the treatment of wastewater contaminated with Ph As.

关键词： Microalgae pharmaceuticals Extracellular polymeric substances Antioxidant enzyme CYP450 enzyme

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Occurrence and distribution of pharmaceuticals in surface water and sediment of Buffalo and Sundays River estuaries, South Africa and their ecological risk assessment

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Emerging Contaminants 2021年第1期7卷 187-195页

作者： Chinemerem Ruth Ohoro Abiodun Olagoke Adeniji Lucy Semerjian Omobola Oluranti Okoh Anthony Ifeanyi Okoh SAMRC Microbial Water Quality Monitoring Centre University of Fort HareAlice5700South Africa Department of Pure and Applied Chemistry University of Fort HareAlice5700South Africa Applied and Environmental Microbiology Research Group Department of Biochemistry and MicrobiologyUniversity of Fort HareAlice5700South Africa Department of Chemistry and Chemical Technology National University of LesothoP.O.180RomaLesotho Department of Environmental Health Sciences College of Health SciencesUniversity of SharjahSharjahUnited Arab Emirates

This study investigated the presence of pharmaceuticals in the water and sediment of Buffalo and Sundays River Estuary,South Africa.Extraction for water and sediment samples was achieved with solidphase extraction and ultrasonic extraction methods,respectively.Quantification of the target analytes was done with UPLC-QTOF-MS.The pH of surface water in all the sampling sites(8.18-10.1)were above the WHO guideline(6.5).A good correlation was observed between the concentrations of analytes with organic matter and organic carbon.Results showed that carbamazepine exhibited the highest concentration(8.75±1.45 mg/kg)of all the pharmaceuticals,while trimethoprim has the highest detection frequency with the highest concentration of 1.62±0.83 mg/kg in the sediment samples.Sulfamethoxazole was below the detection limit in both estuaries.Calculated risk quotients revealed that carbamazepine and trimethoprim could be of potential risk,while caffeine may pose a very low risk to the aquatic organisms investigated.Proper monitoring of the runoff entering Buffalo Estuary is required,being the point of discharge of Buffalo River to the Indian Ocean.Also,the domestic waste discharge from residences in the surroundings of Sundays Estuary should be monitored.

关键词： pharmaceuticals Estuaries Physicochemical parameters Risk assessment Contamination source Correlation

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