The microbiome as a potential diagnostic biomarker for pancreatic ductal adenocarcinoma(PDAC)

作     者：Roseanna C.Wheatley Juan W.Valle Mairéad G.McNamara 

作者机构：Division of Cancer SciencesSchool of Medical SciencesFaculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK Department of Medical OncologyThe Christie NHS Foundation TrustManchesterUK 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2022年第11卷第5期

页      面：752-754页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Surgery adenocarcinoma diagnosis 

摘      要：Pancreatic ductal adenocarcinoma(PDAC)is a major cause of cancer-related death *** recent advances in treatment options,prognosis remains poor,and data estimates from the United States(US)show that PDAC will surpass colorectal cancer to become the second most common cause of cancer-related death by 2040(1).Surgery followed by adjuvant chemotherapy is the only potentially curative treatment option for patients with PDAC;however,the majority present with advanced stage,non-resectable *** diagnosis could improve the dismal prognosis for this patient group,but this remains challenging due to numerous factors including a lack of approved biomarkers and screening programmes,and non-specificity or late presentation of symptoms.