Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis

作     者：Xinghui Wei Wenhao Zhou Zhen Tang Hao Wu Yichao Liu Hui Dong Ning Wang Hai Huang Shusen Bao Lei Shi Xiaokang Li Yufeng Zheng Zheng Guo 

作者机构：Department of OrthopaedicsTangdu HospitalFourth Military Medical UniversityXi’anShaanxi710038China Northwest Institute for Nonferrous Metal ResearchXi’anShaanxi710016China Department of OrthopaedicsXijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China Department of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing100871China 

出 版 物：《生物活性材料(英文)》 (Bioactive Materials)

年 卷 期：2023年第20卷第2期

页      面：16-28页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.51871239 No.32101087 No.52171244) 

主　　题：Polyetheretherktone Porous Magnesium Angiogenesis Osteogenesis 

摘      要：Polyetheretherketone(PEEK)has been an alternative material for titanium in bone defect repair,but its clinical application is limited by its poor *** this study,a porous structural design and activated surface modification were used to enhance the osseointegration capacity of PEEK *** PEEK scaffolds were manufactured via fused deposition modeling and a polydopamine(PDA)coating chelated with magnesium ions(Mg^(2+))was utilized on the *** surface modification,the hydrophilicity of PEEK scaffolds was significantly enhanced,and bioactive Mg^(2+)could be *** vitro results showed that the activated surface could promote cell proliferation and adhesion and contribute to osteoblast differentiation and mineralization;the released Mg^(2+)promoted angiogenesis and might contribute to the formation of osteogenic H-type ***,porous PEEK scaffolds were implanted in rabbit femoral condyles for in vivo evaluation of *** results showed that the customized three-dimensional porous structure facilitated vascular ingrowth and bone ingrowth within the PEEK *** PDA coating enhanced the interfacial osseointegration of porous PEEK scaffolds and the released Mg^(2+)accelerated early bone ingrowth by promoting early angiogenesis during the coating degradation *** study provides an efficient solution for enhancing the osseointegration of PEEK materials,which has high potential for translational clinical applications.