Optimizing aerosolization of a high-dose L-arginine powder for pulmonary delivery
作者机构：Drug DeliveryDisposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVictoria 3052Australia Global and Tropical Health DivisionMenzies School of Health ResearchDarwinNorthern TerritoryAustralia Department of MedicineRoyal Darwin HospitalDarwinNorthern TerritoryAustralia AstraZeneca R&DPepparedsleden 143183 MölndalSweden
出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)
年 卷 期：2015年第10卷第6期
页 面：528-540页
核心收录：
学科分类：08[工学] 0827[工学-核科学与技术]
基 金：The Finnish Cultural Foundation and The Emil Aaltonen Foundation for the financial support
主 题：Pulmonary delivery L-arginine Spray drying Mechanofusion Dry powder inhaler(DPI) Formulation
摘 要：In this study a carrier-free dry powder inhalation(DPI)containing L-arginine(ARG)was *** such,it is proposed that ARG could be used for adjunctive treatment of cystic fibrosis and/or *** processing methods were used to manufacture highdose formulation batches consisting various amounts of ARG and *** formulations were evaluated using several analytical methods to assess suitability for further *** batches had enhanced in vitro aerolization *** future challenges include the highly hygroscopic nature of unformulated ARG powder and identifying the scale of dose of ARG required to achieve the response in lungs.
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