中国特应性皮炎患者与细胞因子基因多态性无关联

作     者：Lee W.R. 吴佳纹 

出 版 物：《世界核心医学期刊文摘（皮肤病学分册）》 (Digest of the World Core Medical JOurnals:Dermatology)

年 卷 期：2006年第2卷第5期

页      面：40-40页

学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学] 

主　　题：特应性皮炎 细胞因子 基因多态性 肿瘤坏死因子 基因分型法 嗜伊红细胞增多 直接测序法 激活子 遗传 

摘      要：Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4,-10,-12B and-13,the IL-4 receptor, tumour necrosis factor (TNF)-α , STAT6, and interferon (IFN)-γ . Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that th e analysed genetic polymorphisms of cytokine genes do not appear to be associate d with AD susceptibility in our Chinese population.